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Two senators strike deal on health subsidies that Trump cut off 10/18/2017 9:00:01 AM October 18, 2017 Two leading senators reached a bipartisan deal on Tuesday to fund critical subsidies to health insurers that President Trump moved just days ago to cut off. The plan by Sens. Lamar Alexander (R-TN) and Patty Murray (D-WA) is an effort to stabilize teetering insurance markets under the Affordable Care Act (ACA). At the White House, virtually as the deal was being announced, Trump voiced support for it while insisting that he would try again to repeal the ACA. The agreement calls for funding the subsidies for 2 years, a step that would provide at least short-term certainty to insurers. (Click for more...) Wisconsin lawmakers push for transparency on prescription drug prices 10/18/2017 9:00:01 AM October 18, 2017 In Wisconsin, three bills introduced by state Rep. Deb Kolste (D-Janesville) call on drug manufacturers and insurance companies to be more transparent about changes in drug pricing and coverage. One of the bills would prevent insurers from suddenly cutting off coverage for a medication, another would require PBMs to register with the state's office of commissioner of insurance before operating in Wisconsin, and the third would require drug manufacturers of name brand and generic prescription drugs to notify the state prior to price increases of more than 25%. (Click for more...) Oral semaglutide vs. placebo and subcutaneous semaglutide for glycemic control in type 2 diabetes 10/18/2017 9:00:01 AM October 18, 2017 A recent Phase II study sought to assess the effect of oral semaglutide on glycemic control in patients with type 2 diabetes. The clinical trial, conducted in 14 countries between December 2013 and December 2014, involved 632 patients with type 2 diabetes and insufficient glycemic control using diet and exercise alone or a stable dose of metformin. Participants were randomized to receive oral semaglutide, subcutaneous semaglutide, or placebo for 26 weeks, with a 5-week followup. (Click for more...) Dental antibiotics could be adding to C. difficile cases 10/18/2017 9:00:01 AM October 18, 2017 In 2013, dentists reportedly wrote 24 million prescriptions for antibiotics—a known risk factor for Clostridium difficile, which can be fatal. Now, new research out of Michigan appears to confirm a connection between dental antibiotic prescribing and C. difficile cases, which approached 500,000 in 2011. (Click for more...) Investigation: The little red drug being pushed on older adults 10/18/2017 9:00:01 AM October 18, 2017 CNN investigators have uncovered an inappropriate prescribing trend in nursing homes involving dextromethorphan hydrobromide–quinidine sulfate (Nuedexta—Avanir Pharmaceuticals). Approved for a rare condition called pseudobulbar affect (PBA), which causes uncontrollable laughing or crying, the drug is carving out a profitable business in the long-term care setting. (Click for more...) CVS Health signs 5-year agreement with Anthem to provide services to support IngenioRx 10/18/2017 9:00:01 AM October 18, 2017 CVS Health has inked a 5-year agreement with Anthem to provide services to support IngenioRx, a new PBM announced by Anthem. Under the agreement, CVS Caremark will manage certain services for IngenioRx, including claims processing and prescription fulfillment. CVS Health's bundled suite of assets, including CVS Pharmacy and MinuteClinic, also enable the company to apply its skill in patient messaging and engagement at the point-of-sale to support IngenioRx. (Click for more...) Cost-effectiveness of testing and treatment for latent TB infection in residents born outside of the United States 10/18/2017 9:00:01 AM October 18, 2017 Researchers evaluated testing and treatment strategies for latent tuberculosis infection (LTBI) in foreign-born residents, an important component in the campaign to achieve U.S. eradication of the disease. Using a simulation model, investigators considered non-native residents with and without HIV infection, end-stage renal disease (ESRD), and diabetes. Based on 10,000 probabilistic simulations, they determined that one strategy or another was almost always cost-effective for these populations. (Click for more...) Minnesota struggles to rein in prescription opioids 10/18/2017 9:00:01 AM October 18, 2017 Although Minnesota has more information than ever before about opioid prescriptions and health officials are responding with a variety of new efforts, the data is still incomplete. The Legislature created a Prescription Monitoring Program in 2007, but only a year's worth of data was retained at any one time in order to protect patient privacy. (Click for more...) Trump drug czar nominee is withdrawing; administration very concerned' about law he championed 10/18/2017 9:00:01 AM October 18, 2017 President Trump announced Tuesday that Rep. Tom Marino (R-PA), his nominee for drug czar, was withdrawing in the wake of an investigative report detailing how he helped pass legislation weakening DEA's to go after drug distributors. The Trump administration's scrutiny of that law has intensified, with Deputy Attorney General Rod Rosenstein saying he is "very concerned about it" and planning to review whether DEA needs "more tools" to carry out its mission. A spokesman for Sen. (Click for more...) Senate committee hears industry testimony on the high cost of drugs 10/18/2017 9:00:01 AM October 18, 2017 The Senate's Health, Education, Labor and Pensions (HELP) Committee on Tuesday heard testimony from pharmaceutical manufacturers and the supply chain in a full committee hearing titled "The Cost of Prescription Drugs: How the Drug Delivery System Affects What Patients Pay." Testifying on behalf of the Pharmaceutical Research and Manufacturers of America, Lori Reilly, the organization’s executive vice president, suggested that drug costs are not, in fact, on the rise. (Click for more...) Generic drug user fees reauthorization: A victory for public health 10/18/2017 9:00:01 AM October 18, 2017 October 1 marked the start of the first reauthorization of the Generic Drug User Fee Amendment (GDUFA). This was a milestone for FDA but also for public health, write Kathleen Uhl, MD, director, Office of Generic Drugs at FDA's Center for Drug Evaluation and Research (CDER), and Michael Kopcha, MD, RPh, director, Office of Pharmaceutical Quality at CDER. "We now have shorter review goals available for applications that are public health priorities," the authors write. (Click for more...) Appeals court tosses $72 million award in talcum powder case 10/18/2017 9:00:01 AM October 18, 2017 An appeals court in Missouri on Tuesday vacated a $72 million award to a woman who had said her long-time use of talcum powder-containing products from Johnson & Johnson contributed to her ovarian cancer. The Missouri Eastern District Court said that Missouri was not the correct location to hear the lawsuit filed by an Alabama woman; the woman died in 2015, just months before her case went to trial in St. Louis Circuit Court. Early last year, a jury awarded her $10 million in actual damages and $62 million in punitive damages. (Click for more...) APhA’s Menighan testifies before Senate on drug pricing 10/17/2017 3:56:39 PM October 17, 2017 APhA Executive Vice President and CEO Thomas E. Menighan, BSPharm, MBA, ScD (Hon), FAPhA, testified in a hearing about drug prices held by the Senate Committee on Health, Education, Labor and Pensions today, driving home the frustration pharmacists often feel when they devote their time to “chasing administrivia” rather than providing care to patients. (Click for more...) Immunotherapy treatments for cancer gain momentum 10/17/2017 9:00:01 AM October 17, 2017 A new partnership between government researchers and drugmakers is the latest sign that immunotherapy treatment for cancer is advancing rapidly. NIH and the National Cancer Institute (NCI) recently announced a $215 million medical collaboration with 11 medical companies, including AbbVie, Novartis AG, and Johnson & Johnson. Meanwhile, a major lymphoma treatment from Kite Pharma could soon receive approval. (Click for more...) Teamsters target drug giant Cardinal Health's response to opioid crisis 10/17/2017 9:00:01 AM October 17, 2017 Cardinal Health is "in the midst of a corporate crisis" over its role in the opioid analgesic epidemic, according to the Teamsters union, which is urging shareholders of Cardinal Health to relieve Cardinal Health CEO George Barrett of his duties as board chairman. The Teamsters accuse Barrett of inadequate leadership while the company faces investigations and multiple lawsuits. The union called on investors to vote to appoint an independent board chairman at Cardinal Health's annual shareholder meeting in November. (Click for more...) 7 million American men carry cancer-causing HPV virus 10/17/2017 9:00:01 AM October 17, 2017 Oral human papillomavirus (HPV) infection is common among men, according to new research. The study, published in the Annals of Internal Medicine, found that 11 million U.S. men and 3.2 million U.S. women had oral HPV infections, including 7 million and 1.4 million, respectively, with HPV strains that can cause cancers of the throat, tongue, and other areas of the head and neck. The new study found the risk of infection was elevated for smokers, those with multiple sexual partners, and for MSM. Senior author Ashish A. (Click for more...) Trump declines to express confidence in drug czar nominee 10/17/2017 9:00:01 AM October 17, 2017 Even as President Trump said Monday that he will declare a national emergency next week to address the opioid epidemic, he came under pressure to abandon a nominee for drug czar who championed legislation undercutting the government’s power to go after pharmaceutical companies that contribute to the crisis. Trump declined to express confidence in Rep. (Click for more...) Reported penicillin allergy appears to increase the risk of SSIs 10/17/2017 9:00:01 AM October 17, 2017 Massachusetts General Hospital (MGH) researchers have found that surgical patients reported to be allergic to penicillin were much more likely to develop surgical site infections than patients with no documented allergy, due to the alternative antibiotics used to prevent such infections. The research was published in Clinical Infectious Diseases and presented at the IDWeek 2017 conference. The researchers reviewed the medical records of nearly 8,400 patients who underwent common surgical procedures at MGH from 2010 through 2014. (Click for more...) CVS Health, Epic team up to help lower drug costs 10/17/2017 9:00:01 AM October 17, 2017 CVS Health and Epic have partnered on a strategic initiative to help reduce drug costs for patients and improve outcomes by providing prescribers with expanded visibility to lower cost alternatives through enhanced analytics and data sharing. Under the agreement, CVS Health will use Epic's Health Planet population health and analytics platform to generate insights on dispensing patterns and behaviors about medication adherence. (Click for more...) Community pharmacy favorites may be catching the common consumer cold 10/17/2017 9:00:01 AM October 17, 2017 Customers may be starting to shop for OTC drugs with a sharper eye for cost and content, potentially hurting consumer health companies who thought they were insulated from changing tastes. Pfizer said last week that it was "reviewing strategic alternatives" for its non-prescription business, a month after German peer Merck made a similar announcement. Meanwhile, the global leader in non-prescription medicine—a joint venture formed in 2015 by GlaxoSmithKline and Novartis—noted a "marked slowdown" in second-quarter results. (Click for more...) Gestational diabetes and long-term CVD risk 10/17/2017 9:00:01 AM October 17, 2017 Women with a history of gestational diabetes (GD) have a modestly elevated risk for cardiovascular disease (CVD), compared with women who did not have gestational diabetes, according to new research. However, that association could be mitigated by adherence to healthy lifestyle factors, including maintaining a healthful diet, physical activity, nonoverweight/nonobese body weight, and not smoking. For the study, researchers analyzed data from the Nurses' Health Study II, an observational cohort study of U.S. (Click for more...) Another record year for U.S. generic drug approvals in 2017 10/17/2017 9:00:01 AM October 17, 2017 FDA's latest fiscal year 2017 activities report reveal that the agency has approved more abbreviated new drug applications (ANDAs) in 2017 than any other year. The 763 approvals (927 approvals and tentative approvals) is 112 more generic approvals than the previous year, 271 more than 2015, and 354 more than in 2014. Meanwhile, the number of complete responses decreased in 2017, from 1,725 in 2016 to 1,603 in 2017. The total number of ANDAs received by FDA also significantly outpaced all prior years as 1,292 were received, which is 439 more than the total ANDAs received last year. (Click for more...) Patents for Allergan's cyclosporine are invalidated 10/17/2017 9:00:01 AM October 17, 2017 United States Circuit Judge William Bryson of the Eastern District of Texas on Monday invalidated four key patents for Allergan's dry-eye treatment cyclosporine (Restasis). Allergan had sought to protect its patents by transferring them to a Native American tribe. The drug manufacturer said that it would appeal the decision. FDA has not yet approved generic versions of the drug. In September, Allergan took the highly unusual step of paying the Saint Regis Mohawk Tribe in upstate New York to take possession of the patents, which then were leased back to the company. (Click for more...) 'Change the conversation' about hormone therapy in menopause 10/17/2017 9:00:01 AM October 17, 2017 Discussions about menopausal hormone therapy over the last 15 years have centered on concerns about elevated risk of breast cancer, heart disease, and dementia. According to North American Menopause Society (NAMS) Executive Director JoAnn Pinkerton, MD, the time has come for clinicians to "change the conversation." Her organization has released a new position statement reassuring the public that hormone therapy is both safe and effective for treating hot flashes, night sweats, and other symptoms that impact quality of life for women in menopause. (Click for more...) Price of cancer drugs rises after launch, unfazed by market 10/17/2017 9:00:01 AM October 17, 2017 A new analysis of injectable oncology drugs demonstrates that prices for the medications generally climb after initial market launch—even if conditions should warrant a drop. The Israeli study examined the cost trajectory of 24 patented products approved from 1996–2012, using average sales prices published by CMS to account for rebates and discounts. After also adjusting for inflation, the investigators determined that the mean cumulative cost increase for the entire group after a follow-up period of 12 years was 36.5%. (Click for more...) Medicare open enrollment begins on October 15, ends December 7 10/17/2017 8:15:21 AM October 17, 2017 It’s that time of year again! In September, CMS announced that the average basic premium for a Medicare prescription drug plan in 2018 is projected to decline to an estimated $33.50 per month. This represents a decrease of approximately $1.20 below the average basic premium of $34.70 in 2017. The Medicare prescription drug plan average basic premium is projected to decline for the first time since 2012. CMS addressed a number of key issues raised by pharmacists in the annual Call Letter: (Click for more...) Effect of application score strategy on interviews offered to PGY-1 pharmacy residency applicants 10/16/2017 6:05:01 PM October 16, 2017 Residency programs may need to spend a large amount of time on the application review process to invite the best candidates for interviews. By using a different scoring strategy, this process could be made more efficient, while still resulting in selection of the most appropriate candidates to interview. The objective of this study was to explore hypothetical scoring strategies for past residency applicants and to determine the percentage of these applicants that would have received an interview offer compared to the program’s standard scoring strategy. (Click for more...) Mediterranean diet, alkaline water may be as effective as PPIs for laryngopharyngeal reflux 10/16/2017 4:15:10 PM October 16, 2017 Treatment of laryngopharyngeal reflux (LPR) with alkaline water and the Mediterranean diet may be as effective as treatment with proton-pump inhibitors (PPIs), according to research published online in JAMA Otolaryngology–Head & Neck Surgery in September. (Click for more...) PTCB names SSgt Mary Johnson CPhT of the Year 10/16/2017 3:59:12 PM October 16, 2017 The Pharmacy Technician Certification Board (PTCB) yesterday recognized Staff Sergeant Mary Johnson as the Certified Pharmacy Technician (CPhT) of the Year. She is the noncommissioned officer in charge of pharmacy services at Geilenkirchen NATO Air Base in Germany—the largest technician-led pharmacy in the United States Air Force. It serves over 2,800 military members and dependents. Today is Pharmacy Technician Day. (Click for more...) Acting Secretary Hargan declares public health emergency in California due to wildfires 10/16/2017 9:00:01 AM October 16, 2017 HHS Acting Secretary Eric D. Hargan has declared a public health emergency in California due to the wildfires that are devastating the state. The declaration, which is effective retroactively to October 8, allows the secretary to issue a waiver under section 1135 of the Social Security Act for the state to enable CMS to take action that gives beneficiaries and their health care providers and suppliers increased flexibility in meeting key health needs. (Click for more...) A multifaceted intervention to improve treatment with oral anticoagulants in atrial fibrillation 10/16/2017 9:00:01 AM October 16, 2017 The IMPACT-AF clinical trial explored whether an educational intervention targeting patients with atrial fibrillation (AF) would improve uptake of oral anticoagulation, which is important for preventing stroke in this population but is underused. The international study randomized 1,184 AF patients at risk of stroke to participate in a multifaceted intervention that included both patient and provider education, with regular monitoring and feedback. Another group of 1,092 participants, meanwhile, received usual care. (Click for more...) In early results, shorter treatment for TB proves effective 10/16/2017 9:00:01 AM October 16, 2017 Preliminary findings from a new study suggest that taking the right antibiotics for 9 months may be as effective against drug-resistant tuberculosis (TB) as taking them for 2 years. The study—which includes 424 patients with drug-resistant TB in Ethiopia, Mongolia, South Africa, and Vietnam—found "favorable outcomes" in about 78% of those treated for 9 months. Clinical trials using the 2-year regimen have seen an 81% success rate. In addition, the shorter regimen appeared to work for patients coinfected with HIV. (Click for more...) House panel directs DEA to reveal pain medication shipments to WV 10/16/2017 9:00:01 AM October 16, 2017 The House Energy and Commerce Committee has directed DEA to turn over data about opioid analgesic shipments to specific areas in West Virginia. The committee wants DEA to reveal the amount of hydrocodone and oxycodone shipped to six areas in the state. The panel has requested the names of the distributors that supplied the drugs and the names of the pharmacies that purchased them. (Click for more...) CHPA launches DXM age-restriction resource for retailers 10/16/2017 9:00:01 AM October 16, 2017 Millions of Americans use OTC medicines containing the cough suppressant dextromethorphan (DXM) to treat their symptoms, but 1 in 30 teens abuse the medicine to get high, according to the 2016 National Institute on Drug Abuse annual Monitoring the Future survey. This has led the Consumer Healthcare Products Association (CHPA) to announce a new initiative to support retailers in states that have adopted laws prohibiting the sale of OTC medicines containing DXM to minors. (Click for more...) California declares state of emergency over deadly hepatitis A outbreak 10/16/2017 9:00:01 AM October 16, 2017 Gov. Edmund G. Brown Jr. of California declared on Friday a state of emergency due to a hepatitis outbreak that has taken at least 18 lives. With the declaration, state health officials can buy additional doses of the hepatitis A vaccine to try to stop the outbreak. "We have the capacity to use as much vaccine as we can get our hands on," said Gil Chavez, MD, state epidemiologist with the California Department of Public Health. The outbreak started in San Diego's homeless community in late 2016; but it has since spread to other areas, including Los Angeles and Santa Cruz counties. (Click for more...) Pharmacists say lower payment rates could push them out of business 10/16/2017 9:00:01 AM October 16, 2017 Pharmacists across Ventura County, CA, warn that payment rates that reduce reimbursements for many Medi-Cal prescriptions could push independent pharmacies out of business. The pharmacists say the lower rates were triggered by changes involving the Gold Coast Health Plan, a publicly funded agency that administers Medi-Cal health insurance to more than 200,000 low-income individuals in Ventura County. A year ago, the commission that governs Gold Coast awarded its contract for managing its medication program to OptumRx, part of the UnitedHealth Group. (Click for more...) Where the FDA is going under Trump 10/16/2017 9:00:01 AM October 16, 2017 FDA Commissioner Scott Gottlieb says part of what his agency does "is issue regulations to try to create a more modern framework for new technologies, new ways of doing business. It isn't a question of regulations or no regulations. I think it is a question for us of smart regulations." He says FDA is committed to the food labeling regulations. "This is an issue of public health," he states. "We have implemented some delays in the implementation of those regulations. (Click for more...) REMS format and content: FDA offers draft guidance 10/16/2017 9:00:01 AM October 16, 2017 On October 11, FDA released updated draft guidance for the format and content of a risk evaluation and mitigation strategy (REMS) document for prescription drugs and biologics. The 34-page draft, which revises 2009 draft guidance, removes information related to REMS assessments and proposed REMS modifications that are being addressed in separate guidance documents. The draft is meant to help ensure REMS documents are clear, understandable, and to the extent possible, consistent in content and format. (Click for more...) Lower license fees for pharmacists, others to cost Missouri $2 million 10/16/2017 9:00:01 AM October 16, 2017 Under new rules from the Missouri Department of Insurance, Financial Institutions, and Professional Registration, thousands of pharmacists, podiatrists, and psychologists in the state will have lower license fees. The rules were filed in stages, with the largest of the proposed changes appearing in the May 1 edition of the Missouri Register. The state Board of Pharmacy first proposed lowering fees for approximately 1,300 pharmacies, 2,600 drug distributors, and 15,405 pharmacy technicians, which amounts to about $1.6 million less in revenue for Missouri. (Click for more...) States sue over Trump-halted ACA payments 10/16/2017 9:00:01 AM October 16, 2017 Eighteen states and Washington, DC, have filed a lawsuit to stop President Trump from halting key Affordable Care Act (ACA) payments to insurers. On October 12, Trump announced he would stop making the payments, which led to an outcry from critics saying he was sabotaging the health care law. The complaint will seek a temporary restraining order, preliminary injunction, and permanent injunction requiring the cost-sharing reduction payments be made. (Click for more...) Walgreens selects IBM to support field services 10/16/2017 9:00:01 AM October 16, 2017 Walgreens will deploy IBM retail analytics at more than 8,100 locations nationwide to enhance its stores' IT systems. The goal is to improve the efficiency of field service support at these locations, according to IBM. The new agreement will integrate IBM's unique capabilities with hardware and software from different vendors under one roof, which is expected to furnish more efficient operation of technology across each store. IBM Cloud also will be used to determine the level of support that will likely be needed at each Walgreens location based on service request history. (Click for more...) Polymorphism, Intermolecular Interactions, and spectroscopic properties in Crystal Structures of Sulfonamides 10/15/2017 6:05:01 PM October 15, 2017 The antibiotics family of sulfonamides has been used worldwide intensively in human therapeutics and farm livestock during decades. Intermolecular interactions of these sulfamides are important to understand their bioactivity and biodegradation. These interactions are also responsible for their supramolecular structures. The intermolecular interactions in the crystal polymorphs of the sulfonamides, sulfamethoxypyridazine and sulfamethoxydiazine, as models of sulfonamides, have been studied by using quantum mechanical calculations. (Click for more...) In vitro-in vivo correlations of carbamazepine nano-dispersions for application in formulation development 10/15/2017 6:05:01 PM October 15, 2017 During formulation development, efficiently integrating in vitro dissolution testing can significantly improve one’s ability to estimate in vivo performance and aide in the selection of premier drug candidates. The concept of in vitro - in vivo relationship/correlation (IVIVR/IVIVC) has garnered significant attention from pharmaceutical scientists to predict expected bioavailability characteristics for drug substances and products. (Click for more...) Effect of Phosphate Ion on the Structure of Lumazine Synthase, an Antigen Presentation System from Bacillus anthracis 10/15/2017 6:05:01 PM October 15, 2017 Lumazine synthase (LS) is an oligomeric enzyme involved in the biosynthesis of riboflavin in microorganisms, fungi and plants. LS has become of significant interest to biomedical science because of its critical biological role and attractive structural properties for antigen presentation in vaccines. LS derived from Bacillus anthracis (BaLS) consists of 60 identical subunits forming an icosahedron. Its crystal structure has been solved, but its dynamic conformational properties have not yet been studied. (Click for more...) Poly(amidoamine) (PAMAM) dendrimers as a pharmaceutical excipient. Are we there yet? 10/15/2017 6:05:01 PM October 15, 2017 Drug solubility could affect the therapeutic use of a drug because the biological activity of a drug is only possible if some fraction of a dissolved drug can permeate and overcome biological membranes to reach its site of action. The solubility-permeation interplay is therefore, probably the most important factor in determining a successful therapeutic outcome of any drug because more than 40% of marketed drugs and more than 70% of pipeline drugs show poor water solubility. (Click for more...) Medication management in Minnesota schools: The need for school nurse-pharmacist partnerships 10/15/2017 6:05:01 PM October 15, 2017 Pharmacist participation in school medication management (MM) is minimal. School nurses are responsible for increasingly complex medication administration and management in schools. (Click for more...) New Drugs: Betrixaban, Voxilaprevir/sofosbuvir/velpatasvir, and Glecaprevir/pibrentasvir 10/15/2017 6:05:01 PM October 15, 2017 (Click for more...) Fabrication and Use of PLGA-based Formulations Designed for Modified Release of 5-Fluorouracil 10/15/2017 6:05:01 PM October 15, 2017 5-fluorouracil (5-FU) is a chemotherapeutic agent that has been used for the treatment of a variety of malignancies since its initial introduction to the clinic in 1957.1 Due to its short biological half-life, multiple dosings are generally required to maintain effective 5-FU plasma concentrations throughout the therapeutic period. Clinical studies have shown that continuous 5-FU administration is generally superior to bolus injection as exhibited by lower toxicities and increased therapeutic efficacy. (Click for more...) Professional liability insurance: Should you carry your own policy? 10/15/2017 1:38:54 PM October 15, 2017 A question I frequently get asked from student pharmacists and my fellow New Practitioners alike is “Should I carry my own liability insurance?” In this article, I will highlight areas where professional liability is necessary, and the pros and cons of carrying it. (Click for more...) Trump to end key ACA subsidies, a move that will threaten the law's marketplaces 10/14/2017 9:00:01 AM October 13, 2017 Making good on months of threats, President Trump on October 12 moved to end federal subsidies that help millions of lower-income Americans afford health coverage. The payments to insurers, worth about $7 billion for 2017, are critical to the marketplaces created by Barack Obama's Affordable Care Act (ACA). Terminating them would provide justification for any carrier to backpedal on its federal contract to sell health plans for next year, causing tremendous disruption. (Click for more...) The Use of a GroEL-BLI Biosensor to Rapidly Assess Pre-Aggregate Populations for Antibody Solutions Exhibiting Different Stability Profiles 10/14/2017 12:05:01 AM October 13, 2017 An automated method using biotinylated GroEL-streptavidin biosensors with Bio-Layer Interferometry (GroEL-BLI) was evaluated to detect the formation of transiently formed, pre-aggregate species in various pharmaceutically relevant monoclonal antibody (mAb) samples. The relative aggregation propensity of various IgG1 and IgG4 mAbs was rank-ordered using the GroEL-BLI biosensor method, and the least stable IgG4 mAb was subjected to different stresses including elevated temperatures, acidic pH, and addition of guanidine-HCl. (Click for more...) Glecaprevir and pibrentasvir in patients with HCV and severe renal impairment 10/13/2017 9:00:01 AM October 13, 2017 Treatment is limited for patients trying to manage both hepatitis C (HCV) and severe renal dysfunction, but a novel combination of two drugs offers promise. To assess the safety and efficacy of glecaprevir and pibrentasvir in this population, a multinational team of researchers executed a Phase III trial. They recruited more than 100 patients with HCV and concomitant stage 4 or 5 chronic kidney disease. Combination therapy was administered for a period of 12 weeks on an open-label basis. (Click for more...) FDA panel endorses gene therapy for a form of childhood blindness 10/13/2017 9:00:01 AM October 13, 2017 The emerging field of gene therapy continues to make strides, the latest milestone coming October 12 as an FDA advisory committee recommended approval of its first use for an inherited disorder. Voretigene neparvovec (Luxturna—Spark Therapeutics) was developed to treat RPE65-mutation associated retinal dystrophy, a rare condition characterized by childhood onset of progressive blindness. Clinical study showed rapid and measurable vision improvement in participants, which was sustained after more than 3 years of followup, with no adverse reaction to the gene therapy itself. (Click for more...) NIH partners with biopharma companies to speed development of new cancer immunotherapies for more patients 10/13/2017 9:00:01 AM October 13, 2017 NIH has teamed up with 11 biopharmaceutical companies to launch the Partnership for Accelerating Cancer Therapies (PACT). The 5-year public-private research collaboration, part of the Cancer Moonshot, will focus initially on efforts to identify, develop, and validate robust biomarkers to advance new immunotherapy treatments that harness the immune system to fight cancer. The Foundation for the National Institutes of Health will manage the partnership, with FDA advising. (Click for more...) Older adults with dementia at risk for inappropriate medications 10/13/2017 9:00:01 AM October 13, 2017 Researchers in Europe who studied more than 2,000 older adults with dementia found that 60% had been prescribed at least one potentially inappropriate medication, while over 25% had received at least two such drugs. Residents of long-term care facilities who were at least 80 years old and had dementia were at greater risk of receiving two or more such potentially unsuitable medicines, according to the study published in Age and Ageing. (Click for more...) Medicare offers improved access to high-quality health coverage choices in 2018 10/13/2017 9:00:01 AM October 13, 2017 CMS has issued the Star Ratings for the 2018 Medicare health and drug plans. With the release of the Star Ratings, individuals covered by Medicare will have greater access to high-quality health choices for their Medicare coverage for 2018. "Medicare is committed to empowering seniors to choose high-quality health and drug plans that fit their needs and the needs of their families," said CMS Administrator Seema Verma. "More high-quality choices mean improved quality care and better customer service at lower cost. (Click for more...) FDA: Ban on free tobacco samples includes e-cigs 10/13/2017 9:00:01 AM October 13, 2017 FDA's ban on free samples of tobacco products includes electronic cigarettes, according to guidance finalized by the agency this week. The ban on free samples of tobacco products covers any tobacco product that is subject to FDA regulation, including components of tobacco products such as e-liquids and refillable cartridges for e-cigarettes. While FDA finalized the regulation prohibiting free samples in 2010, the rule then only applied to cigarettes, including roll-your-own tobacco and smokeless tobacco products. (Click for more...) Warren, Murkowski urge Trump to officially declare opioid epidemic a national emergency 10/13/2017 9:00:01 AM October 13, 2017 Sens. Elizabeth Warren (D-MA) and Lisa Murkowski (R-AK) have called on President Trump to officially declare the nation's opioid epidemic a national emergency. In August, the president said the White House was "drawing documents now" to make such a declaration, which would allow access to greater resources and expedite efforts to respond to the opioid crisis. (Click for more...) Local pharmacists see spike in prescription fraud 10/13/2017 9:00:01 AM October 13, 2017 Elizabeth Vieira, a pharmacist at Pleasant Garden Drug Store in Pleasant Garden, NC, is seeing an increase in people trying to use fraudulent prescriptions to purchase drugs. She says in the past 2 months, pharmacists in her store have encountered at least four fake prescriptions. "Nine times out of 10 we know immediately that it's fake," Vieira said. Patients also have attempted to change dates or dosages on real prescriptions. Vieira noted that once pharmacists check with the doctor and find discrepancies, they call the police. (Click for more...) Bartell Drugs enlists LexisNexis-eRx platform to verify prescribers 10/13/2017 9:00:01 AM October 13, 2017 Bartell Drugs has become the first user of LexisNexis VerifyRx, a platform that performs real-time prescription compliance checks within existing pharmacy workflows. The solution was developed by LexisNexis Risk Solutions and eRx Network. LexisNexis Risk Solutions said the solution leverages eRx's real-time pharmacy connectivity and LexisNexis' provider validation service, covering more than 8.5 million providers. (Click for more...) New study finds perception of risks diluted by lengthy adverse effects list 10/13/2017 9:00:01 AM October 13, 2017 How a drug's adverse effects are listed in direct-to-consumer (DTC) marketing influences the public's perceived level of risk from the product, evidence suggests. In a study series and meta-analysis, investigators from the London School of Business compared responses to different pharmaceutical ads that either listed adverse effects in their entirety or that named only the most serious of them. (Click for more...) CVS Health recognizes its 30,000 pharmacists during American Pharmacists Month 10/13/2017 9:00:01 AM October 13, 2017 As part of American Pharmacists Month, CVS Health is honoring its 30,000 pharmacists. Larry J. Merlo, the company's president and CEO, noted: "As our nation's health care landscape changes, our pharmacists are being called upon to play a broader role in a patient's overall health care team. (Click for more...) Antitumor Efficacy and Toxicity of 5-FU-loaded PLGA Pellets 10/13/2017 6:05:01 AM October 13, 2017 The aim of this study was to formulate a biodegradable implant capable of imparting local anti-tumor activity through the sustained release of the chemotherapeutic agent, 5-fluorouracil (5-FU). Thus injectable pellets ( (Click for more...) The solubility-permeability trade-off of progesterone with cyclodextrins under physiological conditions: Experimental observations and computer simulations 10/13/2017 6:05:01 AM October 13, 2017 This study intended to evaluate the effect of cyclodextrins on the apparent solubility and permeability of lipophilic drugs under physiological conditions and establish in silico model to choose the optimal amount of cyclodextrins for cyclodextrin-containing oral formulations. In order to study the effect of cyclodextrins under physiological conditions, bile salts and lecithin were added into the rat intestinal perfusion solution to simulate the fasted intestinal fluid. (Click for more...) Potential of cationic-polymeric nanoparticles for oral delivery of naringenin: In vitro and in vivo investigations 10/13/2017 6:05:01 AM October 13, 2017 To improve the bioavailability and anticancer potential of naringenin (NRG) by developing a drug-loaded polymeric nano-delivery system. NRG-loaded eudragit E100 nanoparticle (NRG-EE100-NPs) system was developed, and physicochemically characterized. In vivo pharmacokinetic and in vitro cytotoxicity ability of the NRG-EE100-NPs was investigated. In vivo anticancer activity was evaluated in murine BALB/c mice-bearing colorectal tumor. The NRG-EE100-NPs had an optimum mean particle size (430.42±5.78nm), polydispersity index (0.283±0.089) with percent entrapment efficiency (68.83±3.45%). (Click for more...) Stable and Fast-Dissolving Amorphous Drug Composites Preparation via Impregnation of Neusilin® UFL2 10/13/2017 6:05:01 AM October 13, 2017 A promising approach to increase the aqueous solubility, hence the bioavailability, of poorly water-soluble drugs is to convert them into their amorphous state through impregnation into mesoporous silica. Unfortunately, mesoporous silica is not yet available in bulk quantities due to high manufacturing costs. In this work, feasibility of using a commercially available cost-effective mesoporous fine grade Neusilin® UFL2 to prepare amorphous drug composites of two model poorly soluble drugs, Fenofibrate and Itraconazole, is established. (Click for more...) Suitability of the AUC ratio as an indicator of the pharmacokinetic advantage in HIPEC 10/13/2017 6:05:01 AM October 13, 2017 The purpose of this study was to evaluate the area under the concentration time curve (AUC) ratio as an optimal indicator of the pharmacokinetic advantage during hyperthermic intraperitoneal perioperative chemotherapy (HIPEC). (Click for more...) Determination of non-spherical morphology of doxorubicin-loaded liposomes by atomic force microscopy 10/13/2017 6:05:01 AM October 13, 2017 The 3-D morphology of doxorubicin (DOX)-loaded liposomes with a size of ca. 100 nm was characterized by AFM in an aqueous environment. Prolate liposomes appear in accordance with linear expansion of DOX fiber bundles precipitated inside liposomes. Oblate and concave liposomes were simultaneously observed with increased DOX concentrations; however, their morphologies were not readily determined by 2-D cryo-TEM imaging. (Click for more...) New Jersey seeks to expand opioid prescription monitoring to veterinarians 10/12/2017 9:00:01 AM October 12, 2017 New guidelines in New Jersey aim to prevent human abuse of medications prescribed to pets. The guidelines call on veterinarians who prescribe opioids to use the New Jersey Prescription Monitoring Program. Under the program, physicians must consult with the database when prescribing opioids, and pharmacies must report prescription data that is shared with more than a dozen other states. Veterinarians are not required to check the database but are encouraged to participate voluntarily. (Click for more...) Romosozumab or alendronate for fracture prevention in women with osteoporosis 10/12/2017 9:00:01 AM October 12, 2017 For postmenopausal women with osteoporosis at high risk for fracture, romosozumab treatment for a year followed by alendronate led to significantly lower risk of fracture compared with alendronate alone, according to new research. The Phase III study involved more than 4,000 postmenopausal women with osteoporosis and a fragility fracture. The women were randomly assigned to receive monthly subcutaneous romosozumab (210 mg) or weekly oral alendronate (70 mg) in a blinded fashion for 1 year, followed by open-label alendronate for both groups. (Click for more...) Ibuprofen better than morphine for kids after minor surgery 10/12/2017 9:00:01 AM October 12, 2017 The Canadian Medical Association Journal has reported new study results indicating that children should be given ibuprofen—not oral morphine—after minor orthopedic surgery. The clinical trial, performed in Ontario, included 154 patients between the ages of 5 and 17 years. While both approaches worked equally well to relieve pain—although neither completed negated it—adverse effects such as drowsiness, dizziness, nausea, vomiting, and constipation occurred more frequently with morphine. (Click for more...) Epidurals do not prolong labor 10/12/2017 9:00:01 AM October 12, 2017 Contrary to widely held belief, researchers in China have demonstrated that epidural anesthesia administered in the final stage of delivery does not prolong the duration of labor. The evidence comes from a double-blinded trial of 400 laboring patients, each randomly assigned to receive epidural anesthesia or a saline solution. Average time from full cervical dilation to delivery was comparable between the two groups of women, as were the number of forceps deliveries, cesarean sections, and episiotomies. (Click for more...) Community pharmacies support National Check Your Meds Day 10/12/2017 9:00:01 AM October 12, 2017 HHS and the advocacy group Consumer Reports have designated October 21 as National Check Your Meds Day, and community pharmacies such as CVS Health will be participating in the initiative. The idea is for consumers, at least once a year, to take all of their medications to a pharmacist or physician for a "brown bag" review to check for potential harmful drug interactions and possibly eliminate unnecessary drugs. (Click for more...) An old-school pharmacy hand-delivers drugs to Congress 10/12/2017 9:00:01 AM October 12, 2017 As a courtesy to members of Congress, the oldest community pharmacy in the nation's capital shuttles prescription drugs to legislators as well as their families, staffers, and lobbyists. Grubb's, which has been doing business since 1867 and catering to lawmakers for decades, also services the general public. With daily volume of as many as 800 orders, owner Mike Kim employs more than 30 pharmacists, technicians, and support staff—including five drivers. (Click for more...) Pharma's Puerto Rico problems could mean drug shortages: FDA chief 10/12/2017 9:00:01 AM October 12, 2017 FDA Commissioner Scott Gottlieb, MD, says the United States could soon see minor drug shortages due to delays in restoring manufacturing operations in Puerto Rico, which is still recovering from the devastation of Hurricane Maria. Most major drug companies have manufacturing facilities on the island, and 10% of drugs prescribed in the United States are made there. Drugmakers are working to get facilities fully online, but face an unstable power supply and challenges getting materials used in the manufacturing process. Gottlieb predicted U.S. (Click for more...) FDA taking steps to advance patient engagement in the agency's regulatory work 10/12/2017 9:00:01 AM October 12, 2017 FDA on Wednesday hosted the first meeting of the Patient Engagement Advisory Committee, a significant step forward in the agency's efforts to deepen the involvement of patients in its regulatory activities. The advisory committee was founded by FDA's Center for Devices and Radiological Health (CDRH). Involving the patient in identifying health priorities and outcomes desired from health interventions is critically important. (Click for more...) 340B: Health system execs push back on narrowing of drug discount program 10/12/2017 9:00:01 AM October 12, 2017 The House Energy and Commerce's subcommittee on Oversight and Investigations on Wednesday conducted a hearing on the federal 340B drug discount program. Proponents of the program say that the discounts help offset the cost of care for uninsured and low-income patients, while critics warn it can be abused when savings are accrued but not passed on to patients, with many calling for the program to be narrowed or eliminated. (Click for more...) In start to unwinding the health law, Trump to ease insurance rules 10/12/2017 9:00:01 AM October 12, 2017 President Trump is expected to sign on Thursday an executive order that would initiate the unwinding of the Affordable Care Act (ACA). With the order, the president will direct federal agencies to take actions aimed at providing less expensive options and fostering competition in the individual insurance markets. According to two senior White House officials, the specific steps in the order will represent just the first moves in his White House's effort to strike parts of the ACA. (Click for more...) Medicare plans place few restrictions on coverage of prescription opioids, Yale study finds 10/12/2017 9:00:01 AM October 12, 2017 New research from Yale University indicates that Medicare plans have few restrictions on prescription opioid coverage. For the observational study, researchers reviewed prescription drug plan formulary files from CMS in 2006, 2011, and 2015. They included data from Medicare Advantage and Part D plans, looking at coverage for all opioids except methadone. In 2015, one-third of the drugs were prescribed with no restrictions, according to the research. While that figure is down from two-thirds in 2006, the researchers note that a large portion still had no prescribing limitations. (Click for more...) Effects of behavioral interventions on inappropriate antibiotic prescribing in primary care 12 months after stopping interventions 10/12/2017 9:00:01 AM October 12, 2017 Research confirmed that peer comparison and accountable justification—but not suggested alternatives—effectively curtailed inappropriate prescribing of antibiotics for acute respiratory infections (ARIs). However, investigators also wanted to know if these techniques continued to work 1 year after they ended. The study was conducted at 47 primary care practices in Boston and Los Angeles, with participation by nearly 250 clinicians randomly allocated to one, two, or all three interventions—or none at all. (Click for more...) Editorial Advisory Board 10/12/2017 6:05:01 AM November 01, 2017 (Click for more...) In Situ Monitoring and Modeling of the Solution-Mediated Polymorphic Transformation of Rifampicin: From Form II to Form I 10/12/2017 12:05:01 AM October 11, 2017 In this paper, the solution-mediated polymorphic transformation of rifampicin was investigated and simulated in three solvents at 30 °C. The solid state form I and form II of rifampicin was characterized by powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), Raman spectroscopy and fourier transform infrared spectroscopy (FTIR). To explore the relative stability, solubility data of form I and form II of rifampicin in butan-1-ol were determined using a dynamical method. (Click for more...) Modeling and Prediction of Drug Dispersability in Polyvinylpyrrolidone-Vinyl Acetate Copolymer using a Molecular Descriptor 10/12/2017 12:05:01 AM October 11, 2017 The expansion of a novel in silico model for the prediction of the dispersability of 18 model compounds with polyvinylpyrrolidone-vinyl acetate copolymer (PVPva) is described. The molecular descriptor R3m (atomic mass weighted 3rd order autocorrelation index) is shown to be predictive of the formation of amorphous solid dispersions at two drug loadings (15% and 75% w/w) using two preparation methods (melt-quenching and solvent evaporation using a rotary evaporator). (Click for more...) Monitoring the Phase Behavior of Supersaturated Solutions of Poorly Water-Soluble Drugs Using Fluorescence Techniques 10/12/2017 12:05:01 AM October 11, 2017 Phase transformations of poorly water-soluble drugs, in low concentration, supersaturated aqueous solutions are of considerable interest. Herein, fluorescence lifetime and steady-state fluorescence spectroscopy were employed to investigate the fluorescence properties of the autofluorescent compound, felodipine (a 1,4-dihydropyridine calcium channel blocker), when present as free drug in solution, drug-rich aggregates and crystals. Measurements were also performed in the absence and presence of liver microsomes. (Click for more...) Predicting solubility/miscibility in amorphous dispersions: It’s time to move beyond regular solution theories 10/12/2017 12:05:01 AM October 11, 2017 The evolving challenges associated with the development of poorly soluble drug molecules have been met with major advances in drug solubilization. In particular, amorphous solid dispersion technology is becoming an increasingly important option to enhance oral bioavailability by creating prolonged drug supersaturation to maximize the driving force for intestinal absorption. (Click for more...) Understanding Protein-Interface Interactions of a Fusion Protein at Silicone Oil-Water Interface Probed by Sum Frequency Generation Vibrational Spectroscopy 10/12/2017 12:05:01 AM October 11, 2017 Protein adsorbed at the silicone oil-water interface can undergo a conformational change that has the potential to induce protein aggregation upon storage. Characterization of the protein structures at interface is therefore critical for understanding the protein-interface interactions. In this paper, we have applied sum frequency generation (SFG) spectroscopy for studying the secondary structures of a fusion protein at interface and the surfactant effect on protein adsorption to silicone oil-water interface. (Click for more...) New polymorph form of dexamethasone acetate 10/12/2017 12:05:01 AM October 11, 2017 A new monohydrated polymorph of dexamethasone acetate (DEX-II) was crystallized and its crystal structure characterized. The different analytical techniques used for describing its structural and vibrational properties were: single crystal (SCXRD) and polycrystal (PXRD) X-ray diffraction, solid state nuclear magnetic resonance (solid-state NMR), infrared spectroscopy (IR). A Hirshfeld surface (HS) analysis was carried out through self-arrangement cemented by H-bonds observed in this new polymorph. (Click for more...) Community Pharmacist Collaboration with a Patient Centered Medical Home: Establishment of a Patient-Centered Medical Neighborhood and Payment Model 10/12/2017 12:05:01 AM October 11, 2017 To determine the feasibility of a partnership between a community pharmacy and a PCMH by measuring the impact on office and patient-level clinical outcomes. (Click for more...) Trump names Eric Hargan as acting Health Secretary 10/11/2017 9:00:01 AM October 11, 2017 The White House announced Tuesday that President Trump has named Eric Hargan as acting secretary of HHS. Hargan, who was deputy secretary of the agency, previously served on Trump's transition team for HHS. The move comes after Tom Price resigned as HHS secretary in late September following outcry over his use of private charter planes for government transport. (Click for more...) Battle over drug prices shifts back to the states 10/11/2017 9:00:01 AM October 11, 2017 With little happening in the way of federal action to rein in the costs of prescription drugs, some states are taking matters into their own hands. "This is not an issue that’s going away, and it’s clear that patients are demanding action on this topic, and if they can’t succeed on the federal level, then they're going to the states," says Rachel Sachs, an associate law professor at the Washington University School of Law. On Monday, Gov. Jerry Brown of California signed drug pricing transparency legislation that supporters call the most robust law to date. (Click for more...) Tightly-controlled growing operations off to slow start for LA medical marijuana program 10/11/2017 9:00:01 AM October 11, 2017 Patients in Louisiana eligible for therapeutic marijuana under a 2015 law are still months away from having the drug in hand, with the state's medical marijuana program contending with regulations, tightly-controlled growing operations, and a slow selection process. Only the agricultural centers at Louisiana State University (LSU) and Southern University are permitted to grow the medical-grade marijuana, and the law allows a limited number of dispensing pharmacies. (Click for more...) Chicago moves closer to easing pharmacist workload 10/11/2017 9:00:01 AM October 11, 2017 The Chicago City Council Finance Committee on Tuesday approved a measure that would allow Chicago pharmacists to fill prescription orders for no more than 10 patients per hour, in an effort to reduce the workload of pharmacists. It also would require pharmacies to post a list in plain sight showing which pharmacists and technicians have worked shifts longer than 8 hours. The proposal's sponsor, Edward Burke, the committee's chairman, said he hoped to bring the plan up for a vote in the full City Council soon. (Click for more...) Association of insulin pump therapy vs. insulin injection therapy with severe hypoglycemia, ketoacidosis, and glycemic control in T1D 10/11/2017 9:00:01 AM October 11, 2017 German researchers investigated whether rates of severe hypoglycemia and diabetic ketoacidosis were lower with insulin pump therapy compared with insulin injection therapy in children, adolescents, and young adults with type 1 diabetes. The population-based cohort study, conducted at 446 diabetes centers participating in the Diabetes Prospective Follow-up Initiative in Germany, Austria, and Luxembourg, involves patients with type 1 diabetes younger than age 20 years and with diabetes duration of more than 1 year. (Click for more...) Fauci: An HIV vaccine is essential for ending the HIV/AIDS pandemic 10/11/2017 9:00:01 AM October 11, 2017 Although there have been significant advances in the treatment and prevention of HIV, Anthony Fauci, MD—director of the National Institute of Allergy and Infectious Diseases—asserts that "development of an effective HIV vaccine will likely be necessary to achieve a durable end to the HIV pandemic." In a new commentary, Fauci notes that, in theory, effective implementation of existing HIV treatment and prevention methods worldwide could end the HIV pandemic. He points to the more than 30 highly effective anti-HIV drugs on the market as well as strategies such as pre-exposure prophylaxis. (Click for more...) The latest on lice 10/11/2017 9:00:01 AM October 11, 2017 A clinical report on head lice issued by the American Academy of Pediatrics (AAP) in 2015 emphasized the need for careful diagnosis by trained observers. This indicates someone experienced should look at the child's head, looking for lice and not just for nits. Observers also should be aware of local patterns of resistance to anti-lice medications to determine the appropriate selection of OTC or prescription preparations. (Click for more...) FDA approves triamcinolone acetonide ER injectable suspension for OA knee pain 10/11/2017 9:00:01 AM October 11, 2017 FDA has approved triamcinolone acetonide extended-release injectable suspension (Zilretta—Flexion Therapeutics), the first extended-release, intra-articular injection for osteoarthritis knee pain. The nonopioid medicine employs Flexion's proprietary microsphere technology to provide pain relief for 12 weeks. The approval "comes at a time when our society is in urgent need of non-addictive therapies to help the millions of Americans who suffer from this condition," said Michael Clayman, MD, president and CEO of Flexion. (Click for more...) Puerto Rico's health care is in dire condition, 3 weeks after Maria 10/11/2017 9:00:01 AM October 11, 2017 Nearly 3 weeks after Hurricane Maria landed in Puerto Rico, hospitals are running low on medicine and high on patients, as they take in the infirm from medical centers where generators failed. The federal government has sent 10 Disaster Medical Assistance Teams of civilian doctors, nurses, paramedics and others to the island. Four mobile hospitals have been set up in hospital parking lots, and the Comfort, a medical treatment ship, is on the scene. A 44-bed hospital will soon open in badly wrecked Humacao, in the southeast. (Click for more...) Express Scripts to buy medical-benefits manager eviCore for $3.6 billion 10/11/2017 9:00:01 AM October 11, 2017 Express Scripts Holding has agreed to buy eviCore Healthcore, a private medical benefits manager, for $3.6 billion. The Bluffton, SC-based company, which was founded in 1994, will operate as a standalone business unit of Express Scripts. The deal is expected to close by year-end. St. Louis-based Express Scripts is acquiring eviCore from investors TA Associates, Ridgemont Equity Partners, and General Atlantic. (Click for more...) Discontinuing inappropriate medication use in nursing home residents 10/11/2017 9:00:01 AM October 11, 2017 A multi-site Dutch study implemented and evaluated an intervention targeting inappropriate prescribing in the nursing home setting. The research was carried out in 59 long-term care wards, with 426 patient–participants in all. A Multidisciplinary Multistep Medication Review (3MR)—involving critical appraisal of prescribed drugs, a look at the patient's medical history, and dialogue between physician and pharmacists, among other components—was performed for 233 patients in 33 wards. (Click for more...) Compounded bioidentical hormone therapy: Does the regulatory double standard harm women? 10/11/2017 9:00:01 AM October 11, 2017 While use of menopausal hormone therapy products has trended downward in recent years, evidence suggests U.S. women increasingly are turning to compounded bioidentical hormone therapy (cBHT) to combat hot flashes and other symptoms. Pharmacists polled last year, for example, estimated that 26 million–33 million cBHT prescriptions are filled each year. The problem, warn Cynthia A. Stuenkel, MD, of the University of California, San Diego, and JoAnn E. (Click for more...) Pharmacists in Puerto Rico help their communities after Hurricane Maria 10/10/2017 3:45:13 PM October 10, 2017 Despite Puerto Rico’s utter devastation after Hurricane Maria, pharmacists and pharmacy staff who live there are going above and beyond serving patients in their communities, said Justin Coyle, PharmD, senior director of pharmacy operations at Walgreens. “Team members have lost their homes and need basic needs like food, fuel, water, clothing, and shelter,” Coyle said. “Not only are they experiencing the storm as residents of Puerto Rico, they’re helping their community, and they’re helping their patients.” (Click for more...) Members spotlight: Mary Lynn McPherson, PharmD, MA, MDE, BCPS, CPE, and Alexandra McPherson, PharmD, MPH 10/10/2017 1:03:34 PM October 10, 2017 Mary Lynn McPherson (Click for more...) Continuous glucose monitoring for type 2 diabetes results in better glycemic control 10/10/2017 11:32:30 AM October 10, 2017 Compared with usual care, use of continuous glucose monitoring improved glycemic control in patients with poorly controlled type 2 diabetes who were receiving multiple daily injections of basal–bolus, according to results of a trial published in the Annals of Internal Medicine. (Click for more...) Breaking down barriers to antimicrobial stewardship in small hospitals 10/10/2017 11:17:29 AM October 10, 2017 Owing to their success in promoting patient safety at larger institutions, various national regulatory and accreditation agencies have mandated that all hospitals, regardless of size, implement antimicrobial stewardship programs (ASPs). (Click for more...) Evaluation of a trainee-led project to reduce inappropriate PPI infusion in patients with UGIB 10/10/2017 9:00:02 AM October 10, 2017 In an effort to reduce overuse of proton pump inhibitor (PPI) infusions in patients with upper gastrointestinal bleeding (UGIB), a fellow- and resident-led intervention was launched in July 2015. Using the Culture, Oversight, Systems Change, Training framework, the study included electronic health record prompts for physicians to select an appropriate indication for PPI infusion orders, while pharmacists tracked monthly usage of PPI infusions. In addition, education was provided for internal medicine residents, hospitalists, and emergency medicine faculty and residents. (Click for more...) Baxter initiates voluntary nationwide recall of one shipment of intralipid 20% I.V. fat emulsion 10/10/2017 9:00:02 AM October 10, 2017 Baxter International has announced a voluntary recall of one shipment from a single lot of intralipid 20% fat emulsion, 100 mL. The product, which was distributed to hospitals and health care providers between August 11, 2017 and August 31, 2017, was exposed to subfreezing temperatures during transit to a distribution facility. If accidentally frozen, the emulsion droplets will increase in size, creating aggregates that can obstruct pulmonary circulation and lead to serious adverse health consequences. (Click for more...) FDA approves implantable device to treat moderate-to-severe central sleep apnea 10/10/2017 9:00:02 AM October 10, 2017 FDA approved on October 6 a new treatment option for patients with moderate-to-severe central sleep apnea. Central sleep apnea is when the brain fails to send signals to the diaphragm to breathe, which causes an individual to stop breathing during sleep for a period of 10 seconds or more before starting again. The implantable device (Remede System—Respicardia) stimulates a nerve located in the chest that is responsible for sending signals to the diaphragm to stimulate breathing. (Click for more...) Bevacizumab for advanced cervical cancer: Final overall survival and adverse event analysis 10/10/2017 9:00:02 AM October 10, 2017 Bevacizumab won FDA approval for treatment of advanced cervical cancer based on preliminary trial evidence and now, 3 years later, final analysis of the study results has been completed. The Phase III investigation, which opened enrollment in early 2009, randomized participants into one of four arms: I.V. chemotherapy with cisplatin plus paclitaxel or topotecan plus paclitaxel, with or without I.V. bevacizumab. Patients received open-label treatment until disease progression, unacceptable toxic effects, patient withdrawal from the project, or complete response. (Click for more...) Hospitals scramble to avert saline shortage in wake of Puerto Rico disaster 10/10/2017 9:00:02 AM October 10, 2017 Several prominent hospitals across the United States are responding to the disrupted production of widely used intravenous solutions caused by Hurricane Maria by searching for alternative supplies, changing the way they administer drugs, and devising backup plans to make the fluids themselves. The products affected are smaller-volume bags of sodium chloride, known as saline, and dextrose. Their manufacturer, Baxter International, reports that "multiple production days" were lost in the wake of the hurricane, and it has set up an allocation system for hospitals based on past purchases. (Click for more...) Californians will get more information on drug prices under new law 10/10/2017 9:00:02 AM October 10, 2017 Gov. Jerry Brown of California on Monday signed into law a measure to increase disclosure on prescription drug prices. The law will require drugmakers to provide notice to health plans and other purchasers 60 days in advance of a planned price hike if the increase exceeds certain thresholds. The law also requires require health plans to submit an annual report to the state that details the most frequently prescribed drugs, those that are most expensive and those that have been subject to the greatest year-to-year price increase. (Click for more...) Amazon is headed for the prescription-drug market, analysts say 10/10/2017 9:00:02 AM October 10, 2017 Amazon.com Inc. is extremely likely to enter the business of selling prescription drugs by 2019, according to analysts at Leerink Partners. "It's a matter of when, not if," Leerink Partners analyst David Larsen said in a report to clients late Thursday. "We expect an announcement within the next 1-2 years." Leerink's calls with industry experts suggest that Amazon "is in active discussions" with mid-size PBMs and possibly larger player such as Prime Therapeutics, Larsen's colleague, Ana Gupte, wrote in a separate report Friday. (Click for more...) Update: Influenza activity--United States and worldwide 10/10/2017 9:00:02 AM October 10, 2017 In the United States and elsewhere, most documented influenza viruses during May 21–September 23, 2017, were similar to reference viruses representing the recommended components for the 2017–18 vaccine. Overall, activity was typical for the time of year, with low levels reported domestically. Most cases from late May through late June were tied to influenza B, with influenza A viruses becoming more prevalent starting in early July. (Click for more...) In wake of Harvey, Paramount Rx helps cover cost of tetanus vaccines at H-E-B stores 10/10/2017 9:00:02 AM October 10, 2017 Paramount Rx has teamed up with H-E-B to support the distribution of 2,500 tetanus vaccinations at no cost at H-E-B stores in areas hit hard by Hurricane Harvey. "Even as flood waters recede, leftover debris still pose a threat to those who have not received a tetanus booster in the last 10 years," said Ken Hammond, president of Paramount Rx. (Click for more...) Additional delivery of insulin ready for distribution in Puerto Rico 10/10/2017 9:00:02 AM October 10, 2017 Eli Lilly reported on October 5 that a new shipment of commercial medicines, including more than 36,000 vials and pens of insulin, had arrived in Puerto Rico. According to the company, the delivery includes 3,000 vials for humanitarian distribution and enough commercial insulin to help restock operational pharmacies. The company's first humanitarian shipment arrived just a few days after Hurricane Maria hit on September 20, and the total now includes 5,400 insulin pens and vials. (Click for more...) Vaccination challenges in confronting the resurgent threat from yellow fever 10/10/2017 9:00:02 AM October 10, 2017 Widespread distribution of Ae aegypti has renewed fears of yellow fever (YF) outbreaks among urban populations. Not only has the global stockpile of vaccine been depleted, a manufacturing debacle has dried up supplies of the only one (YF-VAX—Sanofi Pasteur) licensed for use in the United States. A new production facility due to start up in 2018 should ease the domestic bottleneck; but, in the meantime, FDA and CDC have allowed Sanofi Pasteur to import a similar vaccine, Stamaril, from France under the investigational new drug (IND) program. (Click for more...) Trump administration rolls back birth control mandate 10/10/2017 9:00:02 AM October 10, 2017 Hundreds of thousands of American women are at risk of losing access to free contraception, after the Trump administration repealed a federal mandate requiring employers to include it in their health care coverage. President Barack Obama's Affordable Care Act had made the protection available at no cost to more than 55 million users. Under new rules issued by HHS, however, any employer—including publicly traded companies—can decline to cover contraceptive services on religious or moral grounds, effective immediately. The timing of the new HHS rules coincide with a memo from U.S. (Click for more...) DHA and pGPMA Dual Modified pH Sensitive Polymeric Micelles for Target Treatment of Liver Cancer 10/10/2017 12:05:01 AM October 09, 2017 In clinical therapy, the poor prognosis of hepatocellular carcinoma (HCC) is mainly attributed to the failure of chemotherapeutical agents to accumulate in tumor as well as lack of potency of tumor penetration. In this work, we developed actively tumor-targeting micelles with pH-sensitive linker as a novel nanocarrier for HCC therapy. These micelles comprised of biodegradable PEG-pAsp polymers, in which PTX can be covalently conjugated to pAsp via an acid-labile acetal bond to form pH-responsive structures. (Click for more...) Encouraging research but challenges remain 10/7/2017 12:05:01 AM October 06, 2017 (Click for more...) Students call for increased efforts to reduce mental health stigma 10/7/2017 12:05:01 AM October 06, 2017 (Click for more...) Insomnia management paramount to mental health 10/7/2017 12:05:01 AM October 06, 2017 (Click for more...) Mechanistic PBPK Modeling of the Dissolution and Food Effect of a BCS IV Compound – the Venetoclax Story 10/7/2017 12:05:01 AM October 06, 2017 Venetoclax, a selective B-cell lymphoma-2 inhibitor, is a biopharmaceutics classification system (BCS) class IV compound. The aim of this study was to develop a physiologically-based pharmacokinetic (PBPK) model to mechanistically describe absorption and disposition of an amorphous solid dispersion (ASD) formulation of venetoclax in humans. (Click for more...) Development of a Modified Release Formulation of Lovastatin Targeted to Intestinal Methanogens Implicated in Irritable Bowel Syndrome with Constipation 10/7/2017 12:05:01 AM October 06, 2017 There is growing evidence that methane production, predominantly by Methanobrevibacter smithii (M. smithii), in the intestines is a cause of constipation, pain and bloating in irritable bowel syndrome with constipation (IBS-C). M. smithii resides primarily in the large intestine but can also colonize the small intestine. In-vitro studies found that the prodrug lactone form of lovastatin, found in cholesterol lowering drugs, inhibited methane production in stool samples from patients with IBS-C. (Click for more...) Trump administration set to roll back birth control mandate 10/6/2017 9:00:01 AM October 06, 2017 The Trump administration is set to issue new roles as soon as Friday that will roll back the federal requirement for employers to include birth control coverage in their health insurance plans, vastly expanding exemptions for those that cite moral or religious objections. More than 55 million women have access to birth control without copayments because of the contraceptive coverage mandate, according to a study commissioned by the Obama administration. (Click for more...) California's deadly hepatitis A outbreak could last years, official says 10/6/2017 9:00:01 AM October 06, 2017 California's outbreak of hepatitis A, already the nation's second largest in the last 20 years, could continue for many months, even years, warned Monique Foster, MD, a medical epidemiologist with the Division of Viral Hepatitis at CDC. At least 569 people have been infected and 17 have died of the virus since November in San Diego, Santa Cruz, and Los Angeles counties, where local outbreaks have been declared. Many areas in the state are beginning to offer vaccines to their homeless populations, which are considered most at risk. (Click for more...) Obinutuzumab for the first-line treatment of follicular lymphoma 10/6/2017 9:00:01 AM October 06, 2017 U.K. researchers compared progression-free survival in patients undergoing two different types of immunochemotherapy for follicular lymphoma. The study included 1,202 treatment-naive participants, one-half of whom were randomized to first-line therapy with rituximab, which has already been demonstrated to improve outcomes in this population. The other 601 participants received first-line treatment with obinutuzumab, a glycoengineered type II anti-CD20 monoclonal antibody. (Click for more...) Delaware panel weighs health, safety issues of legalized pot 10/6/2017 9:00:01 AM October 06, 2017 In Delaware, members of the Adult Use Cannabis Task Force heard Wednesday concerns from law enforcement, the state Chamber of Commerce, and pharmacists. The task force was established after a legalization bill introduced by Rep. Helene Keeley (D-Wilmington) stalled in the legislature earlier this year. The task force, which Keeley co-chairs, faces a January 31 deadline for reporting to the governor and General Assembly. (Click for more...) HHS OIG finds FDA spends user fees appropriately 10/6/2017 9:00:01 AM October 06, 2017 FDA generally spends prescription drug user fees appropriately, according to a new report from HHS' Office of Inspector General (OIG). The report was based on more than $796 million in user fees collected by FDA from October 2014 through September 2015. The review comes soon after the resignation of Tom Price, MD, as HHS secretary due to questions over his use of taxpayer funds for chartered travel. Sen. (Click for more...) NY lawmaker calls for expanded access to HAV vaccine 10/6/2017 9:00:01 AM October 06, 2017 New York should make it easier for the public to be vaccinated against the hepatitis A virus, says a state lawmaker. Sen. Brad Hoylman (D-Manhattan) says he plans to introduce legislation Friday that would allow pharmacists and nurse practitioners in the state to administer the hepatitis A vaccine. Hoylman pointed out that pharmacists and nurse practitioners can already administer vaccines for diseases such as influenza and meningitis. A recent increase in hepatitis A cases in New York highlights the need for expanded access to the vaccine, he said. (Click for more...) U.S. court reverses ban on sale of Regeneron, Sanofi cholesterol drug 10/6/2017 9:00:01 AM October 06, 2017 The U.S. Court of Appeals for the Federal Circuit in Washington on Thursday threw out a ban on the sale of Regeneron Pharmaceuticals and Sanofi's cholesterol-lowering drug alirocumab (Praluent), and ordered a new trial after finding a jury was given improper instructions. The ruling was a setback for Amgen, which claimed the drug infringed patents on its rival drug, evolocumab (Repatha), and had won the sales ban after a jury trial. (Click for more...) New Jersey sues drugmaker Insys over opioid analgesic 10/6/2017 9:00:01 AM October 06, 2017 New Jersey Attorney General Christopher Porrino has filed a lawsuit against Insys Therapeutics, alleging the company fraudulently marketed its fentanyl sublingual spray (Subsys) for widespread use, despite having only received FDA approval to treat severe cancer pain in individuals tolerant of other opioids. The lawsuit, filed in state court in Middlesex County on Thursday, claims that Insys' actions led to the death of a young woman who was prescribed the fentanyl spray for fibromyalgia. (Click for more...) PA to fund opioid overdose antidote for first responders 10/6/2017 9:00:01 AM October 06, 2017 Gov. Tom Wolf of Pennsylvania announced Thursday the state will supply 120,000 doses of naloxone to first responders. According to administration officials, the 2017–18 budget includes $5 million for bulk purchases of naloxone (Narcan nasal spray—Adapt Pharma). More than 4,000 people died from drug overdoses in Pennsylvania last year, a 37% increase from 2015. The increase was driven in large part by fentanyl. (Click for more...) Walgreens recognizes 27,000 pharmacists for their role in health care 10/6/2017 9:00:01 AM October 06, 2017 As part of American Pharmacists Month this October, Walgreens said it is recognizing its thousands of pharmacists for their dedication to patient care as well as the key role they serve in health care today. "Our pharmacists' commitment to Walgreens patients is evident every day, and this year, especially, we've seen countless illustrations of our pharmacists going above and beyond," said Richard Ashworth, Walgreens president of pharmacy and retail operations. (Click for more...) HHS activates aid for uninsured Puerto Rico residents needing medicine 10/6/2017 9:00:01 AM October 06, 2017 HHS' Office of the Assistant Secretary for Preparedness and Response (ASPR) has activated its Emergency Prescription Assistance Program (EPAP) for Puerto Rico to give residents access to the essential prescription drugs they need. The program covers the cost of prescription medications for uninsured individuals who are affected by disasters. "During my time in Puerto Rico this week, I witnessed the extent of the devastation to the island first-hand," said HHS' Assistant Secretary for Preparedness and Response Robert Kadlec, MD. (Click for more...) Hematopoietic stem-cell gene therapy for cerebral adrenoleukodystrophy 10/6/2017 9:00:01 AM October 06, 2017 To date, only allogeneic hematopoietic stem-cell transplantation has been shown to arrest disease progression in patients with cerebral adrenoleukodystrophy, which presents with neurodegeneration and demyelination. An international team of experts conducted a study to evaluate the safety and efficacy of a novel treatment that entails infusing autologous CD34+ cells transduced with the elivaldogene tavalentivec (Lenti-D) lentiviral vector. The main endpoint was survival at 24 months post-infusion with no major functional disability. (Click for more...) Erratum 10/6/2017 6:05:01 AM October 06, 2017 “A systematic review of rapid diagnostic tests for influenza: considerations for the community pharmacist.” J Am Pharm Assoc. 2017;57(1):13-19. (Click for more...) Enhanced Dissolution of a Porous Carrier-Containing Ternary Amorphous Solid Dispersion System Prepared by a Hot Melt Method 10/6/2017 6:05:01 AM October 06, 2017 The focus of our study was to employ a solvent-free, thermal process to evaluate the use of a porous carrier in a drug-polymer-porous carrier ternary formulation containing a high drug load (e.g., ≥50% w/w). The purpose of the study was to improve the dissolution properties of the BCS Class II drug, indomethacin (IND), in the ternary formulation. (Click for more...) Mechanistic basis of cocrystal dissolution advantage 10/6/2017 6:05:01 AM October 06, 2017 Current interest in cocrystal development resides in the advantages that the cocrystal may have in solubility and dissolution compared to the parent drug. This work provides a mechanistic analysis and comparison of the dissolution behavior of carbamazepine (CBZ) and its two cocrystals, carbamazepine-saccharin (CBZ-SAC) and carbamazepine-salicylic acid (CBZ-SLC) under the influence of pH and micellar solubilization. A simple mathematical equation is derived based on the mass transport analyses to describe the dissolution advantage of cocrystals. (Click for more...) How sensitive are transdermal transport predictions by microscopic stratum corneum models to geometric and transport parameter input? 10/6/2017 6:05:01 AM October 06, 2017 While predictive models of transdermal transport have the potential to reduce human and animal testing, microscopic stratum corneum (SC) model output is highly dependent on idealized SC geometry, transport pathway (transcellular vs. intercellular), and penetrant transport parameters (e.g. compound diffusivity in lipids). Most microscopic models are limited to a simple rectangular brick-and-mortar SC geometry and do not account for variability across delivery sites, hydration levels, and populations. (Click for more...) Evaluation of Glass Delamination Risk in Pharmaceutical 10 mL/10R Vials 10/6/2017 6:05:01 AM October 06, 2017 Glass delamination is characterized by the dissociation of glass flakes from the glass surface. Since glass delamination is time dependent, five vial types were investigated to assess delamination under accelerated stress conditions published as quick tests in literature and compared to stress testing recommended per United States Pharmacopoeia (USP). A broad panel of analytical techniques was employed to test the solution for visible/sub-visible particles and leachables, and characterize topography and composition of the surface. (Click for more...) Development of a novel amorphous agomelatine formulation with improved storage stability and enhanced bioavailability 10/6/2017 6:05:01 AM October 06, 2017 The present work describes the development of a novel formulation of amorphous agomelatine (AGM) that exhibits enhanced in vitro dissolution rate and bioavailability, as well as improved storage stability. Agomelatine was loaded on a mixture of microcrystalline cellulose with a high specific surface area excipient, namely colloidal silicon dioxide, employing a wet granulation method and the resultant AGM granules were subsequently formulated into immediate release film-coated tablets. (Click for more...) Optimization of a Vaginal Suppository Formulation to Deliver SHetA2 as a Novel Treatment for Cervical Dysplasia 10/6/2017 6:05:01 AM October 06, 2017 Cervical dysplasia induced by the human papilloma virus (HPV) unpredictably progresses to cervical cancer. Therapeutic options are invasive and affect the patient’s quality of life. SHetA2 has demonstrated therapeutic efficacy against human and murine HPV- induced tumors, but its oral bioavailability is (Click for more...) Drug-Disease Interaction: Effect of inflammation and Nonsteroidal Anti-Inflammatory Drugs on Cytochrome P450 Metabolites of Arachidonic Acid 10/6/2017 6:05:01 AM October 06, 2017 Inflammatory conditions increase cardiovascular (CV) risk. Some nonsteroidal anti-inflammatory drugs (NSAIDs) that are used to treat pain and inflammation are also associated with CV complications. Inflammation, but not NSAIDs, disrupts the balance of vasodilator and vasoconstrictor components of the renin-angiotensin system (RAS) within the heart. Herein, we report the effect of both inflammation and NSAIDs (rofecoxib, celecoxib and meloxicam) on the physiologically active cytochrome P450 (CYP) metabolites of arachidonic acid (ArA) in the rat with adjuvant arthritis (AA). (Click for more...) In vivo transgene expression in the pancreas by the intraductal injection of naked plasmid DNA 10/6/2017 6:05:01 AM October 06, 2017 Patients with type I diabetes, which is caused by the destruction of pancreatic islets, now require regular therapeutic injections of insulin. The use of transgene therapy represents an alternate and potent strategy for the treatment of type I diabetes. However, only a limited number of studies regarding in vivo gene delivery targeting the pancreas and islets have been reported. Here, we report on the possibility of in vivo transgene expression in the pancreas by the intraductal injection of naked plasmid DNA (pDNA). (Click for more...) The use of a 2,2’-azobis (2-amidinopropane) dihydrochloride (AAPH) stress model as an indicator of oxidation susceptibility for monoclonal antibodies 10/6/2017 6:05:01 AM October 06, 2017 Protein oxidation is a major pathway for degradation of biologic drug products. Past literature reports have suggested that AAPH, a free radical generator that produces alkoxyl and alkyl peroxyl radicals, is a useful model reagent stress for assessing the oxidative susceptibility of proteins. (Click for more...) Solubilization of a Poorly Soluble b-RAF (Rapidly Accelerated Fibrosarcoma) Inhibitor: From Theory to Application 10/6/2017 6:05:01 AM October 06, 2017 The oral bioavailability of a drug candidate is influenced by its permeability, metabolism, and physico-chemical properties. Among the physico-chemical properties, solubility and dissolution rate often are the most critical factors affecting the oral bioavailability of a compound. The increasing challenge for the pharmaceutical industry is to achieve reasonable oral bioavailability of poorly water-soluble drug candidates. (Click for more...) Co-Amorphous API-Small Molecule Mixtures: Considerations in the Choice of Co-Formers for Enhancing Dissolution and Oral Bioavailability 10/6/2017 6:05:01 AM October 06, 2017 In recent years, co-amorphous systems, containing an active pharmaceutical ingredient (API) and a small molecule co-former have appeared as alternatives to the use of amorphous solid dispersions containing polymer (ASDs), or co-crystals of API and small molecule co-formers, to improve the dissolution and oral bioavailability of poorly soluble crystalline API. This Commentary considers the relative properties of ASDs and co-amorphous systems in terms of methods of preparation; miscibility; glass transition temperature; physical stability, hygroscopicity; and aqueous dissolution. (Click for more...) Recommendations for patients with diabetes 10/6/2017 6:05:01 AM October 06, 2017 (Click for more...) Characterization of Actions Taken During the Delivery of Medication Therapy Management: A Time-and-Motion Approach 10/5/2017 12:05:01 PM October 05, 2017 To characterize actions performed by pharmacists and support staff during provision of medication therapy management (MTM) and compare actions performed by practice characteristics. (Click for more...) Evaluating Suspension Formulations of Theophylline Cocrystals with Artificial Sweeteners 10/5/2017 12:05:01 PM October 05, 2017 Pharmaceutical cocrystals have garnered significant interest as potential solids to address issues associated with formulation development of drug substances. However, studies concerning the understanding of formulation behaviour of cocrystals are still at the nascent stage. We present results of our attempts to evaluate suspension formulations of cocrystals of an anti-asthmatic drug, theophylline, with two artificial sweeteners. Stability, solubility, drug release and taste of the suspension formulations were evaluated. (Click for more...) Improving the Carprofen Solubility: Synthesis of the Zn2al-Ldh Hybrid Compound 10/5/2017 12:05:01 PM October 05, 2017 The development of efficient strategies for drug delivery is considerably desired. Indeed, often several issues such as the drug solubility, the control of the drug release rate, the targeted delivery of drugs, the drug bioavailability and the minimization of secondary effects still present great obstacles. Different methodologies have been proposed, but the use of nano-hybrids compounds that combine organic and inorganic substances seems particularly promising. (Click for more...) Composite Alginate-Hyaluronan Sponges for the Delivery of Tranexamic Acid in Post-Extractive Alveolar Wounds 10/5/2017 12:05:01 PM October 05, 2017 The management of wounds in patients on anticoagulant therapy who require oral surgical procedures is problematic and often results in a non-satisfactory healing process. Here we report a method to prepare an advanced dressing able to avoid uncontrolled bleeding by occluding the post-extractive alveolar wounds, and simultaneously, capable of a fast release of tranexamic acid (TA). Composite alginate/hyaluronan (ALG/HA) sponge dressings loaded with TA were prepared by a straightforward internal gelation method followed by a freeze-drying step. (Click for more...) Drug chains contribute to Hurricane Maria relief 10/5/2017 9:00:01 AM October 05, 2017 Walgreens, CVS Pharmacy, Rite Aid, and Discount Drug Mart are among the community pharmacies contributing funds and other assistance to Puerto Rico in the wake of Hurricane Maria. Walgreens reported on Wednesday that it has reopened more than one-half of its 120 stores in the U.S. territory. The company is making a $250,000 donation to American Red Cross Hurricane Maria relief effort. Walgreens customers can donate to Red Cross hurricane relief efforts at checkout in Walgreens and Duane Reade stores nationwide and in Puerto Rico. (Click for more...) Incidence of measles in the United States, 2001-2015 10/5/2017 9:00:01 AM October 05, 2017 Although endemic measles was wiped out in the United States in 2000, outbreaks have continued to sprout as a result of the virus being brought in from other countries. CDC researchers analyzed data on all cases occurring from January 2001–December 2015, in an effort to characterize the post-elimination trend. Of particular interest were patients' age, whether or not they had been vaccinated, and importation status. In the 15 years after endemic elimination, 1,789 measles cases were reported among U.S. (Click for more...) Association between use of antithrombotic medication and hematuria-related complications 10/5/2017 9:00:01 AM October 05, 2017 University of Toronto researchers investigated a possible correlation between antithrombotic medications and hematuria-related complications. Their retrospective study included more than 2.5 million Ontario residents aged 66 years and older. From that base population, they identified about 808,900 people who were prescribed one or more oral anticoagulant or antiplatelet drug during the time span of 2002–14. (Click for more...) Mylan announced FDA approval of generic MS drug 10/5/2017 9:00:01 AM October 05, 2017 FDA has approved Mylan's abbreviated new drug applications for glatiramer acetate injection, 40 mg/mL for 3-times-a-week injection that is an AP-rated substitutable generic of Copaxone (Teva) 40 mg/mL, and glatiramer acetate injection 20 mg/mL for once-daily injection, an AP-rated, substitutable generic version of Copaxone 20 mg/mL. The drugs are indicated for the treatment of patients with relapsing forms of multiple sclerosis. (Click for more...) Rivaroxaban with or without aspirin in stable CVD 10/5/2017 9:00:01 AM October 05, 2017 Researchers for the COMPASS trial sought to investigate whether rivaroxaban alone or in combination with aspirin would be more effective than aspirin alone for secondary cardiovascular prevention. The double-blind, randomized study, conducted at more than 600 centers in 33 countries, involved patients with a history of stable atherosclerotic vascular disease. In all, 27,395 individuals were randomly assigned to receive rivaroxaban (2.5 mg twice daily) plus aspirin (100 mg once daily), rivaroxaban (5 mg twice daily), or aspirin (100 mg once daily). (Click for more...) Hurricane damage in Puerto Rico leads to fears of drug shortages nationwide 10/5/2017 9:00:01 AM October 05, 2017 Major pharmaceutical firms and federal officials are scrambling to prevent national shortages of critical drugs for treating cancer, diabetes, and heart disease that are manufactured at 80 plants in hurricane-ravaged Puerto Rico. The U.S. territory has become one of the world's biggest centers for pharmaceutical manufacturing, with its factories making 13 of the world's top-selling brand-name drugs. Drug companies are confronting a range of obstacles on the island, including locating enough diesel fuel for generators to run their factories. (Click for more...) Walgreens expands safe medication disposal program 10/5/2017 9:00:01 AM October 05, 2017 Walgreens—joined by AmerisourceBergen, Blue Cross Blue Shield Association, Pfizer, and Prime Therapeutics—announced Wednesday it is adding safe medication disposal kiosks to another 900 Walgreens stores. When the expansion is complete, the kiosks will be available in about 1,500 Walgreens stores across the country. "We are proud to work with organizations from throughout the health care community to make it even easier for people to dispose of their unwanted medications," said Alex Gourlay, president of Walgreens. (Click for more...) Cigna won't cover oxycodone hydrochloride prescriptions for 2018 10/5/2017 9:00:01 AM October 05, 2017 Cigna announced Wednesday that it will effectively stop covering the cost of use of the opioid oxycodone (OxyContin—Purdue Pharma) by customers of its employer-based health plans beginning in January. Cigna's moves come more than a year after the insurer said it intended to cut opioid use among its customers by 25% by 2019. "Our focus is on helping customers get the most value from their medications—this means obtaining effective pain relief while also guarding against opioid misuse," said Jon Maesner, Cigna's chief pharmacy officer. (Click for more...) Oxford team to test universal influenza vaccine 10/5/2017 9:00:01 AM October 05, 2017 Researchers at Oxford University and the biotech firm Vaccitech plan to launch a 2-year clinical trial involving more than 2,000 patients to evaluate a universal influenza vaccine. The new vaccine works by using proteins found in the core of the influenza virus, rather than those on its surface, and stimulates the immune system by triggering T-cells, rather than antibodies. "We're hoping it will last 2 to 3 years—maybe even 4 years—but we really don't know until we do the trials," said Vaccitech CEO Tom Evans. The new vaccine has already been tested for safety in earlier trials. (Click for more...) Pfizer loses lawsuit against Texas agency that provided drug cost data to senators 10/5/2017 9:00:01 AM October 05, 2017 In a ruling against Pfizer, a judge has declared that Texas lawmakers can access details about how the drugmaker priced drugs offered through the state's Medicaid program. The Texas Health and Human Services Commission in 2016 gave two state legislators, who were drafting budget and legislative proposals, information about Pfizer's negotiated drug pricing rates in the Texas Medicaid program, the most costly health care program administered by the state. (Click for more...) Med-Fast paying $2.7m to settle claims it recycled drugs 10/5/2017 9:00:01 AM October 05, 2017 Med-Fast Pharmacy has agreed to pay nearly $2.7 million to resolve federal claims that it illegally recycled unused nursing home medications and overcharged government insurance programs for diabetic test strips. According to federal prosecutors in Pittsburgh, Med-Fast drivers would pick up unused medications from nursing homes after patients died or otherwise no longer needed the drugs, so they could be used to fill future prescriptions. The older, unused drugs were commingled and relabeled with newer drugs, the prosecutors said. (Click for more...) AllianceRx Walgreens Prime brand makes debut 10/5/2017 9:00:01 AM October 05, 2017 AllianceRx Walgreens Prime, the brand for the joint central specialty pharmacy and mail services company formed by Walgreens and Prime Therapeutics LLC, has launched. The launch included the unveiling of new signage at its headquarters in Orlando and at other company-owned facilities nationwide. Patients will begin to see the AllianceRx Walgreens Prime name and logo on prescriptions and documentation. Walgreens and Prime Therapeutics announced their joint venture just over a year ago. In April, they completed their transaction to form the new pharmacy services company. (Click for more...) Time management app replaces my planner 10/4/2017 10:45:49 PM October 04, 2017 Time management has always been a passion of mine. It was a skill taught to me at a young age, when a color-coded calendar hung on the family fridge to keep track of my dad’s business dinners, my mom’s volunteer work, and the various sports practices and after-school club meetings my brother and I were involved in. As I got older, I realized time management is such a vital skill in managing all of my commitments and activities. (Click for more...) The pursuit of a healthier lifestyle 10/4/2017 10:30:09 PM October 04, 2017 Prior to embarking in higher education, many individuals are warned about the dreaded “Freshman 15.” Those on a protracted academic endeavor may wind up seeing this turn into the “PharmD 30.” While good nutrition, aerobic exercise, and making SMART goals are important, the reality is that grueling academic schedules, residency training, or adapting to life as a New Practitioner often interfere with the best healthy living intentions. (Click for more...) How to make friends in a new city 10/4/2017 10:08:37 PM October 04, 2017 Recently, I accepted a job that moved me to Columbus, OH, a city I had never even visited before. I was worried about a whole slew of things, but the thing that concerned me the most was, “How am I going to make friends in a place where I know no one?” For most of you, your method of finding friends hasn’t changed much since kindergarten—go to class and meet people who like the same things you like. However, once you graduate from pharmacy school, that classroom full of peers is no longer accessible. Instead, you must find a different way. (Click for more...) Moving on from your first real job 10/4/2017 9:54:34 PM October 04, 2017 You are finally ready to start your first real pharmacist job! But, most likely, your first job isn’t the one you will be in for the rest of your career. Once you have worked a year or two, you may realize it’s time to move on. What’s the best way to do this? I have recently gone through this process, and outlined a few tips. How to say good-bye Deciding to leave a job isn’t an easy decision or something that happens overnight. It all depends on the reasons for leaving, your relationship with your supervisor, and your position. (Click for more...) CVS simplifies patient prescriptions with ScriptPath 10/4/2017 9:00:01 AM October 04, 2017 CVS Pharmacy on Wednesday launched the ScriptPath Prescription Schedule, which brings together all of a patient's CVS prescription information into one document and employs icons designating the time of day and dosage for each medication in a patient's regimen. The tool provides information on which drugs the patient takes, when to take them, and how much of each medication to take in each dose. Symbols on the icons indicate morning (rising sun), midday (full sun), evening (setting sun), and bedtime (moon). (Click for more...) Effects of oral vs. transdermal estrogen therapy on sexual function in early postmenopause 10/4/2017 9:00:01 AM October 04, 2017 Researchers questioned whether estrogen therapy, administered orally or through the skin, might mitigate intimacy problems experienced by women in the early years following menopause. The study population included 670 females aged 42–58 years who were already participating in the Kronos Early Estrogen Prevention (KEEPS) study. After randomization, they begin a regimen of oral conjugated equine estrogens (o-CEE), transdermal 17Beta-estradiol (t-E2), or placebo. (Click for more...) For children with severe anxiety, drugs plus therapy help best 10/4/2017 9:00:01 AM October 04, 2017 For children and adolescents with severe anxiety who do not fully respond to drugs or therapy, research indicates that combining the two may help bring their symptoms under control. Nearly 500 young people, aged 7–17 years, participated in the clinical trial funded by the National Institutes of Health. Investigators compared outcomes in patients who were treated with the antidepressant sertraline (Zoloft—Pfizer), a specialized psychotherapy known as cognitive behavior therapy, a combination of both, or placebo. (Click for more...) Bleeding risk in nonvalvular AF on NOACs with vs. without other medications 10/4/2017 9:00:01 AM October 04, 2017 New research out of Taiwan finds that among patients taking non–vitamin K oral anticoagulants (NOACs) for nonvalvular atrial fibrillation, concurrent use of amiodarone, fluconazole, rifampin, and phenytoin compared with the use of NOACs alone, there was an association with greater risk of major bleeding. The retrospective cohort study sought to determine the association between use of NOACs with and without concurrent medications and risk of major bleeding in patients with nonvalvular atrial fibrillation. (Click for more...) FDA: Case of HORV after injections of a compounded TMV formulation 10/4/2017 9:00:01 AM October 04, 2017 FDA is warning that it received an adverse event report about a patient who was diagnosed postoperatively with bilateral hemorrhagic occlusive retinal vasculitis (HORV) after receiving injections of a compounded triamcinolone, moxifloxacin, and vancomycin (TMV) formulation in each eye following cataract surgery procedures that were performed 2 weeks apart. The TMV formulation was compounded by Imprimis Pharmaceuticals, of Ledgewood, NJ. (Click for more...) Cancers associated with overweight and obesity make up 40% of cancers diagnosed in U.S. 10/4/2017 9:00:01 AM October 04, 2017 There are 13 types of cancer associated with overweight and obesity, and these cancers accounted for approximately 40% of all cancers diagnosed in the United States in 2014, CDC reports. According to the latest Vital Signs report, about 630,000 people in the United States were diagnosed with a cancer tied to overweight and obesity in 2014. About two-thirds of the cases occurred in individuals aged 50–74 years. (Click for more...) Rite Aid honors its Pharmacy Champions 10/4/2017 9:00:01 AM October 04, 2017 Rite Aid, in celebration of American Pharmacists Month, is recognizing its more than 11,000 pharmacists for all they do throughout the year. "Our pharmacy teams are passionate about their customers and they show this each and every day, in big and little ways," said Jocelyn Konrad, Rite Aid executive vice president of pharmacy. (Click for more...) 870,000 Americans used $50,000 worth or more of prescription medicine in 2016 10/4/2017 9:00:01 AM October 04, 2017 The number of Americans representing annual medication costs of $50,000 or greater increased by 35% from 2014 to 2016, according to new research by Express Scripts. The survey estimated that 870,000 people accounted for $80 billion, or more than 20%, of total U.S. pharmacy spending in 2016. In contrast, almost 83% of Americans generated less than $1,000 in annual drug costs last year, including approximately a third who had zero drug costs. (Click for more...) Hepatitis C drug's lower cost paves way for Medicaid to expand treatment 10/4/2017 9:00:01 AM October 04, 2017 Glecaprevir–pibrentasvir (Mavyret—Abbvie) is the first FDA-approved drug that can cure all six genetic types of hepatitis C in about 2 months in patients who have not previously been treated. Other approved drugs generally require 12 weeks to treat the disease and often are not effective for all types of hepatitis C. In addition, the drug's price tag of $26,400 for a course of treatment is significantly below that of other hepatitis C drugs whose sticker price ranges from about $55,000 to $95,000 to beat the disease. (Click for more...) Tri-Regulator Collaborative release position statements addressing EHRs, practitioner burnout 10/4/2017 9:00:01 AM October 04, 2017 The Tri-Regulator Collaborative—which represents the governing boards of the three organizations representing the state boards that license physicians, nurses, and pharmacists: the Federation of State Medical Boards, National Association of Boards of Pharmacy, and National Council of State Boards of Nursing—has drafted and approved two position statements that highlight the organizations' commitment to protect public health. (Click for more...) ACLU sues over FDA restrictions on abortion drug access 10/4/2017 9:00:01 AM October 04, 2017 The American Civil Liberties Union (ACLU) on Tuesday filed a lawsuit challenging FDA restrictions that limit the ability of women to access an abortion drug. ACLU filed the lawsuit in U.S. District Court in Hawaii to challenge FDA restrictions that limit the dispensing of the drug, mifepristone (Mifeprex—Danco Labs), to clinics, medical offices, or hospitals rather than community pharmacies. (Click for more...) Expanded access: FDA describes efforts to ease application process 10/4/2017 9:00:01 AM October 04, 2017 FDA Commissioner Scott Gottlieb discusses his agency's efforts to ease the application process for new treatments. Each year, FDA receives more than 1,000 applications for the treatment of patients through expanded access, also known as compassionate use. "FDA recognizes that time is critical for these seriously ill patients who do not have alternative therapies, and who cannot take part in a clinical trial of an investigational therapy," says Gottlieb. (Click for more...) Schools of Medicine and Pharmacy alumni are WVU 2017 Homecoming Award recipients 10/4/2017 12:00:00 AM Three School of Medicine alumni and a School of Pharmacy graduate are being recognized by the WVU Alumni Association as 2017 Homecoming Award recipients. (Click for more...) Discussion leaders named for Post-Charlottesville Town Hall 9/19/2017 12:00:00 AM Seven volunteer discussion leaders will take part in the Health Sciences-WVU Medicine Town Hall this Wednesday (Sept. 20) at noon in the Patteson Auditorium at WVU. (Click for more...) WVU, WV attorney general expand eighth grade drug prevention program 9/12/2017 12:00:00 AM West Virginia Attorney General Patrick Morrisey and West Virginia University have partnered to expand a program aimed at sharing drug abuse prevention information with eighth grade students in West Virginia. The initiative, launched in March with the West Virginia University School of Nursing, now also involves West Virginia University's School of Pharmacy and two other universities. (Click for more...) Student and faculty international travel grants available 9/1/2017 12:00:00 AM In honor of the legacy of a long-time staff member in WVU's Global Health Program, the Global Engagement Office (GEO) at Health Sciences is pleased to announce that the application period for the Nancy Sanders Memorial Student Travel Grant and the Nancy Sanders Memorial Faculty Research Abroad Grant is now open. (Click for more...) WVU health care simulation week kicks off Sept. 12 8/30/2017 12:00:00 AM September 12 kicks off national Health Care Simulation Week, and the WV STEPS Center welcomes visitors to a series of events highlighting simulation education. (Click for more...) WVU in the News - Study aims to increase effectiveness of opioid addiction treatment 8/15/2017 12:00:00 AM A new study being conducted at WVU is aimed at increasing the effectiveness of addiction treatment. As many as 20 percent of people addicted to opioids will not respond to the standard treatment of suboxone. Genetic background is one of several factors WVU and the West Virginia Clinical and Translation Science Institute will study to provide better more patient-specific addiction treatment. Get the full story on WV Always. (Click for more...) West Virginia health research gets $55 million boost 8/1/2017 12:00:00 AM MORGANTOWN, W.Va. – Recommitting themselves to bring the benefits of research out of labs and hospitals and into the lives of West Virginia people and communities, a coalition of federal agencies, universities, hospitals and clinics will develop dozens of efforts over the next five years to battle addiction and cancer and reduce the impact of cardiovascular and neurological diseases. (Click for more...) Academy of Excellence in Teaching and Learning applications being accepted 7/20/2017 12:00:00 AM The WVU Health Sciences Faculty Development Program is now accepting applications, CVs and biographies for the 2017 Academy of Excellence in Teaching and Learning. (Click for more...) WVCTSI and WVU research aims to increase addiction treatment effectiveness 7/13/2017 12:00:00 AM MORGANTOWN, W.Va. – Up to 20 percent of people with opioid use disorder may not respond to standard treatment. A new study at West Virginia University seeks to understand why. (Click for more...) Madhavan named to Fulbright Specialist Roster 7/10/2017 12:00:00 AM The U.S. State Department has added S. Suresh Madhavan, Ph.D., of the WVU School of Pharmacy to Fulbright Specialist Roster for the next three years. (Click for more...) Leukemia Research Foundation supports cancer research at WVU 7/5/2017 12:00:00 AM The Leukemia Research Foundation has awarded $100,000 to Wei Du, M.D., Ph.D., of the West Virginia University Cancer Institute to investigate a method for increasing the effectiveness of stem cell transplantation. (Click for more...) Town Hall to focus on heart care and research Thursday, June 15 6/6/2017 12:00:00 AM Two WVU Medicine heart specialists will be the special guests at an open forum for Health Sciences and WVU Medicine faculty, staff, and students at noon on Thursday, June 15, in the Okey Patteson Auditorium in the Health Sciences Center. (Click for more...) Meet the Graduates: Lindsey Glotfelty 5/16/2017 12:00:00 AM When asked what she wanted people to know about her, Lindsey Glotfelty of Finzel, Maryland, stated it's not really what she wants people to know about her, but rather the messages she wants them to get. She has four lessons that she has learned in her life, and they are the principles by which she lives. (Click for more...) ASK WVU MEDICINE: Breast to Brain Cancer - Risks and Research 5/15/2017 12:00:00 AM Join Hannah Hazard-Jenkins, M.D. and Paul Lockman, Ph.D., doctors who are dedicating their efforts to research and treatment of breast cancer, at the next Ask WVU Medicine Community Conversation, Tuesday, May 23 at 6 p.m. in the WVU Health Sciences Center Fukushima Auditorium. (Click for more...) WVU School of Pharmacy's Suresh Madhavan recipient of Distinguished Pharmacy Alumni Award from Purdue University 5/9/2017 12:00:00 AM S. Suresh Madhavan, MBA, Ph.D., was the recipient of Purdue University College of Pharmacy's 2017 Distinguished Pharmacy Alumni Award. Dr. Madhavan was one of four Purdue alumni who received this award, which recognizes the recipient's outstanding achievements in professional and scientific endeavors. (Click for more...) Cancer researcher is first alum to lead WVU School of Pharmacy 4/26/2017 12:00:00 AM William (Bill) Petros, PharmD, FCCP, has been appointed to the position. (Click for more...) WVU recognizes Health Sciences staff and faculty 4/10/2017 12:00:00 AM West Virginia University honored 13 individuals and two teams at the Health Sciences Center for outstanding achievement on Wednesday, April 12 at 4 p.m. in the Pylons Lobby. (Click for more...) Frank Alderman, MD, to speak at WVU College of Business and Economics Distinguished Speaker Series 4/3/2017 12:00:00 AM Frank Alderman, MD, CEO of MedExpress and a graduate of the WVU Schools of Medicine and Pharmacy, will speak at the WVU College of Business and Economics's Distinguished Speaker Series on April 19 at 3:30 p.m. at the Morgantown Event Center. (Click for more...) WVU and WVCTSI fund two addiction projects 3/29/2017 12:00:00 AM MORGANTOWN, W.Va. – The West Virginia University (WVU) Addiction Task Force and West Virginia Clinical and Translational Science Institute (WVCTSI) have funded two new research projects to combat the opioid epidemic in the state. According to the Centers for Disease Control and Prevention, West Virginia continues to be devastated by this epidemic, having the highest rate of drug overdose deaths in the nation. (Click for more...) Vera Bradley Bingo Relay for Life fundraiser 3/28/2017 12:00:00 AM The West Virginia University School of Pharmacy Relay for Life Team and the Lambda Kappa Sigma student organization will be hosting a Vera Bradley Bingo at 1 p.m. on Sunday, April 2, in room 1909 at the WVU Health Sciences Center in Morgantown. Doors open at noon. (Click for more...) WVU health professions students provide information on fall risk prevention 3/24/2017 12:00:00 AM Students from the West Virginia University School of Pharmacy and School of Medicine Division of Physical Therapy visited Sundale Rehabilitation – Long Term Care on March 22 to discuss fall risk prevention. (Click for more...) FDA Outlines Conditions for Pharmacies to Repackage Drug Products 3/9/2017 7:00:00 PM A guidance issued by FDA on January 12 makes clear that the agency does not favor some long-standing habits of pharmacy personnel related to the repackaging of drug products. (Click for more...) Maine Pharmacists Eye Legislation to End Drug Plans' Retroactive Fees 3/9/2017 7:00:00 PM Direct and indirect remuneration (DIR) fees are a "dragon" that pharmacists in Maine are trying to slay, says Felicity Homsted, chief pharmacy officer for Penobscot Community Health Care (PCHC) in Bangor and president of the Maine Society of Health-System Pharmacists (MSHP). (Click for more...) Alabama Pharmacists Push for State Collaborative Therapy Law 3/9/2017 7:00:00 PM The February 7 start of Alabama's 2017 legislative session is a fresh opportunity for the state to codify collaborative drug therapy management (CDTM) as part of pharmacy practice. (Click for more...) HSC Interprofessional Education Week celebration is March 27-31 3/6/2017 12:00:00 AM Join us for the inaugural HSC Interprofessional Education Week celebration (Click for more...) New pharmacy scholarship honors longtime West Virginia pharmacist 3/6/2017 12:00:00 AM The Jack H. Smith Family Pharmacy Scholarship was established not only to honor Suzanne Smith-Fox's father, but to assist a student who holds the same values as her father – generosity, community involvement, quality citizenship and an outstanding passion for receiving an education. Jack was a 1956 graduate from the West Virginia University School of Pharmacy, and the endowed scholarship also honors Jack's father (Suzanne's grandfather) who was a pharmacist in Parkersburg, West Virginia. (Click for more...) Abuse Potential of Noncontrolled Drugs Often Overlooked, Official Says 2/26/2017 7:00:00 PM To get a real handle on drug abuse, clinicians need to look beyond opioids and consider the abuse potential of noncontrolled drugs, says Michael Cohen, operations officer for the investigations branch of the Department of Health and Human Services (HHS) Office of Inspector General (OIG) in Washington, D.C. (Click for more...) Updated Research Rule Aims for Friendlier Consent Process 2/26/2017 7:00:00 PM It's not just full-time researchers who need to grapple with the recently revised Common Rule, a federal regulation that underpins U.S. research involving human subjects. (Click for more...) Pharmacists Turn Naloxone Training Programs into Video for Broad Audience 2/26/2017 7:00:00 PM A pharmacy project to train emergency medical services (EMS) and law enforcement personnel in how to administer naloxone in cases of opioid overdose has grown into an educational effort that features a video aimed at any potential responder. (Click for more...) Family Focus Helps Pharmacist Improve Diabetes Care for Native Americans 2/12/2017 7:00:00 PM When Cherith Smith started work about a decade ago as a pharmacist at the Missoula Urban Indian Health Center in Montana, she saw a common thread of hopelessness in people with diabetes who visited the center. (Click for more...) VA Project Expands Clinical Pharmacy Services to Rural Veterans 2/12/2017 7:00:00 PM A major project at the Department of Veterans Affairs (VA) to position pharmacists as healthcare providers in rural settings is poised to generate new data on how pharmacists improve patient care. (Click for more...) Proposed Legislation, CMS Guidance Portend Advancements for Pharmacists 2/12/2017 7:00:00 PM Federal efforts to advance pharmacists' role in healthcare got off to a fast start in January with developments including the following: (Click for more...) Deflazacort Approved for Duchenne Muscular Dystrophy 2/9/2017 7:00:00 PM FDA and Marathon Pharmaceuticals LLC on February 9 announced the approval of deflazacort oral tablets and oral suspension for the treatment of Duchenne muscular dystrophy in patients 5 years of age or older. (Click for more...) WVU School of Pharmacy receives reaccreditation 2/9/2017 12:00:00 AM The West Virginia University School of Pharmacy's Doctor of Pharmacy (Pharm.D.) professional program recently received continued accreditation by the Accreditation Council for Pharmacy Education (ACPE). The accreditation is valid until 2025—a full eight years, which is the maximum length of time for ACPE's accreditation. (Click for more...) Baugh named director of interprofessional education for health sciences 12/19/2016 12:00:00 AM Gina M. Baugh, Pharm.D., associate professor and director of Introductory Pharmacy Practice Experiences at the West Virginia University School of Pharmacy, has been named director of interprofessional education for the WVU Health Sciences Center. (Click for more...) DEA registration renewal process changing 12/19/2016 12:00:00 AM As of January 1, 2017, those with an expired DEA registration will need to fully reapply; the DEA will no longer allow a grace period for expired registrants. (Click for more...) WVU Pharmacy students educate youth about substance and prescription drug abuse 10/31/2016 12:00:00 AM Second-year students at the West Virginia University School of Pharmacy visited West Preston School on Thursday, Oct. 27, to discuss the dangers of substance and prescription drug abuse. (Click for more...) WVU student pharmacists offer health screenings at Bridge Day 10/14/2016 12:00:00 AM MORGANTOWN, W.Va. — Students from the West Virginia University School of Pharmacy will be offering a variety of health screenings and information Saturday, Oct. 15, from 9 a.m. – 3 p.m. at Bridge Day at New River Gorge in Fayetteville, West Virginia. (Click for more...) WVU's food bank to open second location, The Rack II@HSC 10/6/2016 12:00:00 AM West Virginia University Health Sciences will soon open "The Rack II@HSC," WVU Health Sciences' Campus Food Bank, to assist with campus-wide efforts to address the growing population of homeless and/or hungry employees/students. (Click for more...) WVU Pharmacy student writes song to benefit disaster relief efforts 9/22/2016 12:00:00 AM MORGANTOWN, W.Va. — You never know from where a source of inspiration might come. (Click for more...) Griffith named WVU Medicine vice president of cancer services 9/21/2016 12:00:00 AM Niesha L. Griffith, a graduate of the West Virginia University School of Pharmacy, has returned to her alma mater as vice president of cancer services for WVU Medicine. She began her new role Sept. 13. (Click for more...) NIH awards WVU $1.8 million to widen health options for children 9/21/2016 12:00:00 AM Seriously ill children across West Virginia will have easier access to new medical treatments in their own communities, thanks to a four-year, $1.8 million grant awarded to West Virginia University today by the National Institutes of Health. (Click for more...) WVU to mark Morgantown Overdose Awareness Day with panel discussion 8/23/2016 12:00:00 AM Makalynn, a WVU student in a 12-step recovery program, is among the WVU and Morgantown representatives who will take part in a panel discussion at 7 p.m. Wednesday, Aug. 31, at the Mountainlair. (Click for more...) WVU Pharmacy students receive white coats 8/13/2016 12:00:00 AM When Deborah Pope of Martinsburg, West Virginia, was in middle school, she knew she wanted to be a health care professional when she grew up. A friend suggested becoming a pharmacist, and the more Pope researched the profession, she discovered it was the right career for her. (Click for more...) WV-INBRE program brings faculty and student researchers across the state to WVU and Marshall for research experience 8/10/2016 12:00:00 AM West Virginia University and Marshall University received a grant for approximately $16 million dollars in 2014 to be distributed over the course of five years from the National Institutes of Health (NIH) to support an Institutional Development Award (IDeA) Network of Biomedical Research Excellence (INBRE). (Click for more...) Change comes from within 8/8/2016 12:00:00 AM West Virginia University's responsibility as the state's Land Grant University is to use the power of knowledge and human connection to lift up people everywhere in our state. But as they say on airplanes, in an emergency you should put on your own oxygen mask first, before you attempt to help others. You can't be much help if you gasping for air. That's why WVU's vice president for health sciences has asked a group of leaders from across WVU Medicine and the Health Sciences Center – and outside our campus – to join the new Quality of Life Initiative. (Click for more...) WVU School of Pharmacy's Terry Schwinghammer recipient of national educator award 8/3/2016 12:00:00 AM Terry Schwinghammer, Pharm.D., was the recipient of the American Association of Colleges of Pharmacy (AACP) Robert K. Chalmers Distinguished Pharmacy Educator Award. (Click for more...) WVU offers free opioid use disorder training to West Virginia healthcare providers 7/20/2016 12:00:00 AM WVU is offering a free American Society of Addiction Medicine buprenorphine course, along with a one-day continuing education event, in two different locations in West Virginia – August 20 in Morgantown and September 17 in Charleston. (Click for more...) WVU Health Outcomes Ph.D. students receive accolades at international conference 6/17/2016 12:00:00 AM Graduate students in the West Virginia University School of Pharmacy Health Outcomes Research Ph.D. program were the recipients of several awards during the International Society of Pharmacoeconomics and Outcomes Research (ISPOR) 21st Annual International Meeting. The meeting was held May 21–25 in Washington, D.C. (Click for more...) Two from WVU named BioWV leaders 5/23/2016 12:00:00 AM Two WVU researchers have been named to the leadership of BioWV, the Bioscience Association of West Virginia, a nonprofit organization that promotes the state's growing bioscience business community. (Click for more...) West Virginia University offers courses to reduce opioid use 5/3/2016 12:00:00 AM West Virginia University has added a new online course, "The Treatment of Pain and Addiction Utilizing Education and Proper Prescribing: The New Paradigm Continued." The course will provide West Virginia physicians, physician assistants, nurses, and dentists with continuing education credit, and also fulfill the state's requirement for training in avoiding diversion of prescriptions drugs into the illicit market. (Click for more...) Wigner Institute hosts AADE workshop 4/20/2016 12:00:00 AM The WVU School of Pharmacy Wigner Institute for Advanced Pharmacy Practice, Education, and Research sponsored an American Association of Diabetes Educators Workshop on April 18. Attendees included pharmacists, nurses, and dietitians from clinics, hospitals, pharmacies, and health departments from 40 counties throughout the state. (Click for more...) WVU BOG approves new degree programs, receives update on Beckley campus 4/19/2016 12:00:00 AM The WVU Board of Governors gave final approval to repurpose an existing School of Pharmacy Ph.D. track into its own independent doctoral program, which will offer a new doctor of philosophy degree in health services and outcomes research. (Click for more...) Outstanding Graduate Student and Mentor awards ceremony 4/13/2016 12:00:00 AM On April 8, 2016, the Office of Research and Graduate Education recognized the achievements and participation of our graduate students in the research, teaching and service missions of the Health Science Center. As part of this ceremony, awards were given to faculty who are outstanding mentors and to graduate students who are outstanding in their graduate programs. (Click for more...) Inspiring Students 4/6/2016 12:00:00 AM I had a lot of fun recording some video with students from each of the Health Sciences schools Tuesday for a back to school video in the fall. (Click for more...) WVU student pharmacists host Senior Olympics 4/1/2016 12:00:00 AM Students from the West Virginia University School of Pharmacy hosted a Senior Olympics for local seniors to stress the importance of physical fitness. (Click for more...) Going global for health education 1/14/2016 12:00:00 AM Beginning in January 2016, faculty and students of the West Virginia University School of Pharmacy will gain a new global opportunity for education and collaboration. (Click for more...) Gold and Blue celebration in Oman 1/13/2016 12:00:00 AM More than 110 newly-graduated health professionals – decked out in West Virginia University's gold-and-blue colors – received diplomas from Oman Medical College Sunday (Jan. 10) in an outdoor ceremony at the Intercontinental Muscat Hotel. (Click for more...) Pack the Rack success 1/13/2016 12:00:00 AM WVU Health Sciences and WVU Medicine faculty, students, and staff donated 944 food items to The Rack – the WVU student food bank – during the "Pack the Rack" holiday drive in November and December, according to Jacqueline Dooley, The Rack program director. (Click for more...) Dr. Clay Marsh meets with Oman health minister 1/11/2016 12:00:00 AM In a meeting Sunday with Oman's minister of health, WVU's vice president for health sciences discussed health challenges common to people and communities in Oman and West Virginia. (Click for more...) New Practitioner Mentor Program 7/16/2012 12:39:22 PM October 11, 2017 The purpose of the APhA New Practitioner Mentor Program is to provide student pharmacists the opportunity to interact with a new practitioner who can provide insight into the transition from student to...Only Member or Student have full access to this content. Log in to view full content. (Click for more...)
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